142688-40-2

Upstream product

• 84828-97-7 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione 
• 146952-84-3 1-((2R,4S,5R)-5-Hydroxymethyl-3-methylene-4-trityloxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 
• 146952-83-2 3',5'-di-O-acetyl-2'-deoxy-2'-methylene-β-D-uridine 
• 102789-14-0 1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-pyrimidine-2,4(1H,3H)-dione 
• 142688-38-8 (3'R)-3'-O-benzoyl-2'-deoxy-2'-methylidene-5'-O-trityluridine 
• 119410-95-6 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 76-83-5 trityl chloride 
• 146952-85-4 O²,3'-anhydro-2'-deoxy-2'-methylidene-5'-O-trityluridine 
• 142688-37-7 Methanesulfonic acid (2R,3S,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-methylene-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 143599-49-9 Methanesulfonic acid (2R,3R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-methylene-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 142688-36-6 2'-deoxy-2'-methylidene-5'-O-trityluridine 
• 142688-39-9 (3'R)-2'-deoxy-2'-methylidene-5'-O-trityluridine 

Relevant academic research and scientific papers

Nucleosides and nucleotides. 124. Chemical reactivity of the sugar moiety of 2'-deoxy-2'-methylidene pyrimidine nucleosides: Synthesis of 3'-amino-2',3'-dideoxy-2'-methylidene pyrimidine nucleosides via [2,3]-sigmatropic rearrangement of allylic selenides

Nucleophilic substitution reactions of an allyl alcohol system in the 2'-deoxy-2'-methylidene pyrimidine nucleosides with various nucleophiles were investigated. The allyl alcohol system reacted with softer nucleophiles such as azide, thiophenoxide, and i

Synthesis of branched nucleosides closely related to AZT, involving SN2′ opening of anhydronucleosides

Three 2′,3′-unsaturated pyrimidine nucleosides, bearing an azido-methyl group at 2′ or 3′ were synthesized as potential anti-HIV agents. The key step involves an SN2′ opening of 2,2′ or 2,3′-anhydronucleosides by azide ion.

NUCLEOSIDES AND NUCLEOTIDES. 110. -SIGMATROPIC REARRANGEMENT OF THE ALLYLIC SELENIDES TO ALLYLIC AMINES IN SUGAR MOIETY OF PYRIMIDINE NUCLEOSIDES: SYNTHESIS OF 3'-AMINO-2',3'-DIDEOXY-2'-METHYLIDENECYTIDINE

An allylic alcohol system in 2'-deoxy-2'-methylideneuridine derivative (4) was converted into the allylic selenide, 2',3'-didehydro-2',3'-dideoxy-2'-phenylselenomethyl derivative (11), which was treated with NCS and tert-butyl carbamate to afford a -