146952-85-4

Upstream product

• 146952-83-2 3',5'-di-O-acetyl-2'-deoxy-2'-methylene-β-D-uridine 
• 102789-14-0 1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-pyrimidine-2,4(1H,3H)-dione 
• 119410-95-6 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 84828-97-7 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione 
• 146952-84-3 1-((2R,4S,5R)-5-Hydroxymethyl-3-methylene-4-trityloxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 
• 142688-36-6 2'-deoxy-2'-methylidene-5'-O-trityluridine 

Downstream Products

• 142688-40-2 2'-azidomethyl-2',3'-didehydro-2',3'-dideoxy-5'-O-trityluridine 

Relevant academic research and scientific papers

Nucleosides and nucleotides. 125. Synthesis and biological evaluation of 2',3'-dideoxy-3'-fluoro-2'-methylidene pyrimidine nucleosides

Reaction of 2'-deoxy-2'-methylidene-5'-O-trityluridine (1) with diethylaminosulfur trifluoride (DAST) in CH2Cl2 resulted in the formation of a mixture of (3'R)-2',3'-dideoxy-3'-fluoro-2'-methylidene derivative 3 and 2',3'-didehydro-2

Synthesis of branched nucleosides closely related to AZT, involving SN2′ opening of anhydronucleosides

Three 2′,3′-unsaturated pyrimidine nucleosides, bearing an azido-methyl group at 2′ or 3′ were synthesized as potential anti-HIV agents. The key step involves an SN2′ opening of 2,2′ or 2,3′-anhydronucleosides by azide ion.