1427219-16-6Relevant articles and documents
Synthesis of the polyketide (E)-olefin of the jamaicamides
Watanabe, Satoshi,Watanabe, Sho,Aoki, Naoto,Usuki, Toyonobu
, p. 1397 - 1403 (2013/05/22)
The jamaicamides, isolated in Jamaica from the cyanobacterium Lyngbya majuscula, are new mixed polyketide-peptides that are known to be sodium channel blockers. The polyketide moiety contains an (E)-vinyl chloride, an undetermined methyl stereocenter (C9), and an (E)-olefin. Herein, we report the synthesis of the (E)-olefin moiety of the polyketide of the jamaicamides utilizing a Kocienski-Julia coupling. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.