14277-20-4Relevant academic research and scientific papers
Difluoro methylation reagent, preparation method and application thereof (by machine translation)
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Paragraph 0342; 0343; 0344; 0346; 0347; 0348, (2017/10/23)
The present invention discloses a two-trifluoromethylation of the reagent, preparation method and application thereof. The invention [...] methylation reagent preparation process is simple, high yield; and the reagent can be a more moderate, high-efficiently the sulfonic acid, alcohol, carbonyl and on the α carbon atom of the difluoromethyl. (by machine translation)
Cu(i)-mediated 18F-trifluoromethylation of arenes: Rapid synthesis of 18F-labeled trifluoromethyl arenes
Rühl,Rafique,Lien,Riss
supporting information, p. 6056 - 6059 (2014/05/20)
This report is concerned with an efficient, CuI-mediated method for the radiosynthesis of [18F]trifluoromethyl arenes, abundant motifs in small molecule drug candidates and potential radiotracers for positron emission tomography. Thr
New electrophilic difluoromethylating reagent
Surya Prakash,Weber, Csaba,Chacko, Sujith,Olah, George A.
, p. 1863 - 1866 (2008/02/04)
A new electrophilic difluoromethylating reagent has been developed. The S-(difluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic difluoromethyl group into the following nucleophiles: sulfonic acids, tertiary amines, imidazole derivatives, and phosphines. The reagent failed to transfer the difluoromethyl group to phenols, carbon nucleophiles, and primary and secondary amines.
Perfluoro- and Polyfluorosulfonic Acids. 21. Synthesis of Difluoromethyl Esters Using Fluorosulfonyldifluoroacetic Acid as a Difluorocarbene Precursor
Chen, Qing-Yun,Wu, Sheng-Wen
, p. 3023 - 3027 (2007/10/02)
Difluoromethyl alkanoates 5 and fluorinated and nonfluorinated alkanesulfonates 9 were synthesized in moderate yields by the reaction of alkali metal salts of acids with fluorosulfonyldifluoroacetic acid (3) in acetonitrile under mild conditions.The presumed intermediate anion FO2SCF2CO2- generates CF2: by elimination of SO2, CO2, and F-.The esters are formed by insertion of CF2: into the O-H of the acid, whereas HCF3 is formed by the competing capture of F-.Organic acids can be used indirectly in the reaction in the presence of inorganic salts such as Na2SO4 and KCl, with comparable yields of difluoromethyl esters.
