142776-07-6

Upstream product

• 100-39-0 benzyl bromide 
• 130930-25-5 (R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 
• 51-35-4 4-hydroxyproline 
• 501-53-1 benzyl chloroformate 
• 197079-48-4 trans-N-(Benzyloxycarbonyl)-4-hydroxy-L-proline 

Downstream Products

• 1190194-25-2 C₃₃H₄₁N₂O₆P 
• 77871-03-5 ester benzylique de la N-(benzyloxycarbonyl)-O-(2,3,5-tri-O-benzyl-α-L-arabinofuranosyl)-L-hydroxyproline 
• 77871-03-5 2-N-(benzyloxycarbonyl)-4-O-(2,3,5-tri-O-benzyl-α-L-arabinofuranosyl)-L-hydroxyproline benzyl ester 
• 77871-03-5 2-N-(benzyloxycarbonyl)-4-O-(2,3,5-tri-O-benzyl-β-L-arabinofuranosyl)-L-hydroxyproline benzyl ester 
• 77884-93-6 ester benzylique de la N-(benzyloxycarbonyl)-O-(2,3,4-tri-O-benzyl-β-L-arabinopyranosyl)-L-hydroxyproline 
• 77884-93-6 ester benzylique de la N-(benzyloxycarbonyl)-O-(2,3,4-tri-O-benzyl-α-L-arabinopyranosyl)-L-hydroxyproline 
• 142896-74-0 (2R,4S)-4-acetoxy-1,2-pyrrolidinedicarboxylic acid 1,2bis(phenylmethyl) ester 
• 142796-93-8 (2R,4S)-4-acetoxy-D-proline 

Relevant academic research and scientific papers

Cu(i)-Functionalized SBA-16: An efficient catalyst for the synthesis of α-ketoamides under moderate conditions

An efficient catalyst based on the cage-like mesoporous material SBA-16 as the support and Cu(i) as active sites has been successfully prepared. The catalyst demonstrated high catalytic activity (up to 88%) in the direct oxidative synthesis of α-ketoamides between acetophenone and piperidine, employing O2 from open air as the oxidant without other additives. A heterogeneous catalyst was applied in this reaction for the first time, and the catalyst could be easily separated from the reaction system by filtration and reused several times without a significant loss of activity.

Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative

In response to various exogenous stimuli, mast cells (MCs) release a wide variety of inflammatory mediators stored in their cytoplasmic granules and this release initiates subsequent allergic reactions. Lysophosphatidylserine (lysoPS) has been known as an exogenous inducer to potentiate histamine release from MCs, though even at submicromolar concentrations. In this study, through SAR studies on lysoPS against MC degranulation, we identified lysoPT, a threonine-containing lysophospholipid and its 2-deoxy derivative as novel strong agonists. LysoPT and its 2-deoxy derivative induced histamine release from MCs both in vitro and in vivo at a concentration less than one-tenth that of lysoPS. Notably, lysoPT did not activate a recently proposed lysoPS receptor on MCs, GPR34, demonstrating the presence of another undefined receptor reactive to both lysoPS and lysoPT that is involved in MC degranulation. Thus, the present strong agonists, lysoPT and its 2-deoxy derivative, will be useful tools to understand the mechanisms of lysoPS-induced activation of degranulation of MCs. 2009 American Chemical Society.

PREPARATION OF (1R,4R)-1-METHYL-2-(p-TOLUENESULFONYL)-5-PHENYLMETHYL-2,5-DIAZABICYCLOHEPTANE, INTERMEDIATE IN A SYNTHESIS OF NEW NAPHTHYRIDONES

An efficient chiral synthesis of the (1R,4R)-1-methyl-2-(p-toluenesulfonyl)-5-phenylmethyl-2,5-diazabicycloheptane (2b) was performed using trans-4-hydroxy-L-proline as starting material.This bridged piperazine was used in the preparation of new na