142799-06-2Relevant academic research and scientific papers
Synthesis of 2-alkoxy(aroxy)-3-substituted Quinolines by DABCO-promoted cyclization of o-alkynylaryl isocyanides
Zhao, Jiaji,Peng, Changlan,Liu, Lanying,Wang, Yong,Zhu, Qiang
supporting information; experimental part, p. 7502 - 7504 (2011/02/21)
Diversified 2-alkoxy- and 2-aroxy-3-substituted quinolines were synthesized from o-alkynylaryl isocyanides and alcohols and phenols promoted by DABCO, respectively. The reaction was initiated by nucleophilic addition of DABCO to isocyanide and subsequent
Cupric halide-mediated intramolecular halocyclization of N-electron-withdrawing group-substituted 2-alkynylanilines for the synthesis of 3-haloindoles
Shen, Zengming,Lu, Xiyan
supporting information; experimental part, p. 3107 - 3112 (2010/04/28)
A convenient and efficient method for the synthesis of 3-haloindoles has been developed. Both 3-chloro-and 3-bromoindole derivatives can be obtained in high yields by the reaction of N-electron-withdrawing group-substituted 2-alkynylanilines with cupric h
New Access to 2,3-disubstituted Quinolines through Cyclization of o-Alkynylisocyanobenzenes
Suginome, Michinori,Fukuda, Takeshi,Ito, Yoshihiko
, p. 1977 - 1979 (2008/02/11)
(Matrix Presented) o-Alkynylisocyanobenzenes underwent nucleophile-induced intramolecular cyclization to give 2,3-disubstituted quinoline derivatives in high yields. In addition to the oxygen and nitrogen nucleophiles such as methanol and diethylamine, the nucleophilic carbon of the enolate of malonate induced the cyclization effectively. Reaction of 1,4-di(trimethylsilylethynyl)-2,3-diisocyanobenzene with methanol afforded 2,9-dimethoxy-1,10-phenanthroline in good yield.
Syntheses of Camalexin, Indolopyridocoline and Flavopereirine
Fuerstner, Alois,Ernst, Andreas
, p. 773 - 786 (2007/10/02)
A short synthetic route to the phytoalexin camalexin 7 and a convergent approach to the alkaloids indolopyridocoline 8, 6,7-dihydroflavopereirine 15 and flavopereirine 9 are presented.Starting from well accessible precursors, these total syntheses highlight the preparative potential of a new method for indole synthesis based on the formation of the C2-C3 bond by low-valent titanium induced reductive coupling of oxo-amides.
