916601-14-4Relevant academic research and scientific papers
Cupric halide-mediated intramolecular halocyclization of N-electron-withdrawing group-substituted 2-alkynylanilines for the synthesis of 3-haloindoles
Shen, Zengming,Lu, Xiyan
supporting information; experimental part, p. 3107 - 3112 (2010/04/28)
A convenient and efficient method for the synthesis of 3-haloindoles has been developed. Both 3-chloro-and 3-bromoindole derivatives can be obtained in high yields by the reaction of N-electron-withdrawing group-substituted 2-alkynylanilines with cupric h
Condensed Heteroaromatic Ring Systems. XIII. One-Step Synthesis of 2-Substituted 1-Methylsulfonylindoles from N-(2-Halophenyl)methanesulfonamides
Sakamoto, Takao,Kondo, Yoshinori,Iwashita, Shigeki,Nagano, Tatsuo,Yamanaka, Hiroshi
, p. 1305 - 1308 (2007/10/02)
The reaction of N-(2-bromophenyl)- and N-(2-iodophenyl)methanesulfonamide with terminal acetylenes in the presence of dichlorobis(triphenylphosphine)palladium yielded 1-methylsulfonylindoles having carbon-functional groups at the 2-position, such as hydroxymethyl, 2-hydroxyethyl, diethoxymethyl, 2-ethoxycarbonylethyl, etc., in one step.Keywords - palladium-catalyzed reaction; dichlorobis(triphenylphosphine)palladium; N-(2-halophenyl)methanesulfonamide; acetylene; 2-substituted 1-methylsulfonylindole.
