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The chemical "5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-N4-benzoyl-2'-deoxy-2',2'-difluorocytidine" is a complex organic compound with a molecular formula of C49H51F2N4O9P. It is a modified nucleoside, specifically a derivative of 2'-deoxy-2',2'-difluorocytidine, which is a type of nucleoside analog used in the synthesis of certain nucleic acid sequences. The compound features a 5'-O-(4,4'-dimethoxytrityl) group, which serves as a protecting group for the 5'-hydroxyl group, and a 3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite) group, which is used for the formation of phosphite triesters during the synthesis of oligonucleotides. Additionally, the N4-benzoyl group provides protection for the exocyclic amino group of the cytidine base. 5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-N4-benzoyl-2'-deoxy-2',2'-difluorocytidine is utilized in the field of molecular biology and chemistry, particularly in the synthesis of modified nucleic acids for research and therapeutic applications.

142808-44-4

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142808-44-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 142808-44-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,8,0 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 142808-44:
(8*1)+(7*4)+(6*2)+(5*8)+(4*0)+(3*8)+(2*4)+(1*4)=124
124 % 10 = 4
So 142808-44-4 is a valid CAS Registry Number.

142808-44-4Downstream Products

142808-44-4Relevant academic research and scientific papers

Biological and physicochemical characterization of siRNAs modified with 2',2'-difluoro-2'-deoxycytidine (gemcitabine)

Sierant, Malgorzata,Sobczak, Milena,Janicka, Magdalena,Paduszynska, Alina,Piotrzkowska, Danuta

, p. 918 - 924 (2010)

The use of synthetic short interfering RNAs (siRNAs) is currently a method of choice to manipulate gene expression in mammalian cells. Efforts aimed at improving siRNA biological activity, including increased silencing properties, higher substrate specifi

Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy

Ma, Yuan,Yang, Jiapei,Zhang, Chuan,Zhu, Lijuan,Zhu, Xinyuan

, p. 1493 - 1497 (2022/02/10)

Owing to the specific and high binding affinity of aptamers to their targets, aptamer-drug conjugates (ApDCs) have emerged as a promising drug delivery system for targeted cancer therapy. However, in a conventional ApDC, the aptamer segment usually just s

Targeting nano carrier bearing nucleoside anti-tumor drugs and preparation method and application thereof

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Paragraph 0080; 0087-0088, (2019/02/04)

The invention provides a targeting nano carrier bearing nucleoside anti-tumor drugs and preparation method and application thereof. The targeting nano carrier comprises DNA tetrahedron, Affibody molecule and nucleoside anti-tumor drugs. The preparation me

COMPOSITION CONTAINING MODIFIED DERIVATIVES OF A CYTIDINE ANTIMETABOLITE FOR THE TREATMENT OF SUSCEPTIBLE DISEASE

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Page/Page column 12, (2015/02/02)

The present invention relates to homo-oligomeric derivatives of a cytidine antimetabolite and its use for the treatment of susceptible diseases. The cytidine antimetabolite is preferably a compound made of 2-20 units of dFdC linked with 5' - 3' phosphate

Novel oligonucleotides and related compounds

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Page/Page column 16, (2008/06/13)

The present invention relates generally to oligonucleotides and more specifically to oligonucleotides which have a sequence including at least two CDG dinucleotides and a prodrug of an antimetabolite. The prodrug can be part of a CpG dinucleotide or may be attached elsewhere on the oligonucleotide.

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