142827-03-0Relevant articles and documents
Application of the Michaelis-Arbusov Reaction to the Synthesis of Internucleoside 3'-S-Phosphorothiolate Linkages
Li, Xiang,Scott, Gerard K.,Baxter, Anthony D.,Taylor, Roger J.,Vyle, Joseph S.,Cosstick, Richard
, p. 2123 - 2130 (2007/10/02)
The 5'-O-monomethoxytrityl-3'-S-(aryldisulfanyl)-3'-deoxythymidines 7 and 8 have been prepared by the reaction of 5'-O-monomethoxytrityl-3'-thiothymidine with the appropriate arenesulfenyl chloride.These disulfides undergo a Michaelis-Arbusov reaction wit
New methods for the synthesis of 3'-S-phosphorothiolate internucleoside linkages
Vyle,Li,Cosstick
, p. 3017 - 3020 (2007/10/02)
Efficient procedures are described for the synthesis of dinucleoside phosphorothiolates using either a Michaelis-Arbusov-type reaction or a phosphotriester approach.