142827-02-9

Upstream product

• 528-76-7 2,4-dinitrobenzenesulfenyl chloride 
• 119005-68-4 5′-O-(mono-p-methoxytriphenylmethyl)-3′-deoxy-3′-thiothymidine 

Downstream Products

• 142827-04-1 C₄₃H₄₇N₄O₁₃PS 
• 142827-10-9 C₄₂H₄₅N₄O₁₃PS 
• 142827-03-0 O,O-dimethyl 5'-O-monomethoxytrityl-3'-thiothymidin-3'-yl phosphorothiolate 
• 119009-80-2 C₄₅H₄₈N₅O₁₃PS 
• 161790-71-2 C₄₇H₅₉N₄O₁₂PSSi 

Relevant academic research and scientific papers

New methods for the synthesis of 3'-S-phosphorothiolate internucleoside linkages

Efficient procedures are described for the synthesis of dinucleoside phosphorothiolates using either a Michaelis-Arbusov-type reaction or a phosphotriester approach.

Application of the Michaelis-Arbusov Reaction to the Synthesis of Internucleoside 3'-S-Phosphorothiolate Linkages

The 5'-O-monomethoxytrityl-3'-S-(aryldisulfanyl)-3'-deoxythymidines 7 and 8 have been prepared by the reaction of 5'-O-monomethoxytrityl-3'-thiothymidine with the appropriate arenesulfenyl chloride.These disulfides undergo a Michaelis-Arbusov reaction wit

Application of an Intramolecular Michaelis-Arbusov Reaction to the Synthesis of Nucleoside 3'-S,5'-O-Cyclic Phosphorothiolate Triesters

An intramolecular Michaelis-Arbusov reaction taking place between a 5'-phosphite and a 3'-S-disulfide can be used to prepare nucleoside 3'-S,5'-O-cyclic phosphorothiolate triesters.