142865-84-7Relevant academic research and scientific papers
Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase
Sukhorukov, Alexey Yu.,Nirvanappa, Anilkumar C.,Swamy, Jagadish,Ioffe, Sema L.,Nanjunda Swamy, Shivananju,Basappa,Rangappa, Kanchugarakoppal S.
, p. 3618 - 3621 (2014/07/22)
Thirteen 2-oxazine-based small molecules were synthesized targeting 5-lipoxygenase (LOX), and acetylcholinesterase (AChE). The test revealed that the newly synthesized compounds had potent inhibition towards both 5-LOX and AChE in lower micro molar concen
A convenient procedure for the synthesis of 3-substituted 5,6-dihydro-4H-1,2-oxazines from nitroethane
Sukhorukov, Alexey Yu.,Klenov, Michael S.,Ivashkin, Pavel E.,Lesiv, Alexey V.,Khomutova, Yulya A.,Ioffe, Sema L.
, p. 97 - 107 (2007/12/31)
A novel and efficient four-step procedure for the synthesis of C-3-functionalised 5,6-dihydro-4H-1,2-oxazines from nitroethane is described. It includes preparation of 3-methyl-substituted six-membered cyclic nitronates, 3-(bromomethyl)-substituted 5,6-dihydro-4H-1,2-oxazines as intermediates, and nucleophilic substitution of bromine. Total yields of the target C-3-functionalised oxazines are 15-30% from nitroethane. Georg Thieme Verlag Stuttgart.
2-Silyloxy-1,2-oxazines, a New Type of Acetals of Conjugated Nitroso Alkenes
Tishkov, Alexander A.,Lesiv, Alexey V.,Khomutova, Yulya A.,Strelenko, Yury A.,Nesterov, Ivan D.,Antipin, Michael Yu.,Ioffe, Sema L.,Denmark, Scott E.
, p. 9477 - 9480 (2007/10/03)
3-Alkyl-substituted 1,2-oxazine N-oxides 2 can be selectively transformed into 2-silyloxy-1,2-oxazines 1 upon treatment with silylating reagents. In the solid state derivatives 1 adopt a chair conformation with the pyramidal nitrogen atom, whereas in solu
Inter- and Intramolecular Cycloadditions of Nitroalkenes with Olefins. 2-Nitrostyrenes
Denmark, Scott E.,Kesler, Brenda S.,Moon, Young-Choon
, p. 4912 - 4924 (2007/10/02)
Aromatic nitroalkenes 9 - 12 underwent Lewis acid catalyzed cycloadditions with various cyclic alkenes to afford high yields of nitronates 25 - 30 with exclusive anti selectivity.Hammett studies helped to further delineate the role of the Lewis acid.Reaction of nitroalkenes 8 and 10 with various cyclic dienes in the presence of a Lewis acid demonstrated the ability of nitroalkenes to behave as dienes in cycloadditions.The major products were the syn diastereomers which arise from an endo-folded transition structure.Finally, intramolecular cycloaddition of 36 - 39 allowed a correlation between the stereochemical course of the reaction and positions of sp2 centers in the tether to be addressed.
