142865-84-7Relevant articles and documents
Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase
Sukhorukov, Alexey Yu.,Nirvanappa, Anilkumar C.,Swamy, Jagadish,Ioffe, Sema L.,Nanjunda Swamy, Shivananju,Basappa,Rangappa, Kanchugarakoppal S.
, p. 3618 - 3621 (2014/07/22)
Thirteen 2-oxazine-based small molecules were synthesized targeting 5-lipoxygenase (LOX), and acetylcholinesterase (AChE). The test revealed that the newly synthesized compounds had potent inhibition towards both 5-LOX and AChE in lower micro molar concen
2-Silyloxy-1,2-oxazines, a New Type of Acetals of Conjugated Nitroso Alkenes
Tishkov, Alexander A.,Lesiv, Alexey V.,Khomutova, Yulya A.,Strelenko, Yury A.,Nesterov, Ivan D.,Antipin, Michael Yu.,Ioffe, Sema L.,Denmark, Scott E.
, p. 9477 - 9480 (2007/10/03)
3-Alkyl-substituted 1,2-oxazine N-oxides 2 can be selectively transformed into 2-silyloxy-1,2-oxazines 1 upon treatment with silylating reagents. In the solid state derivatives 1 adopt a chair conformation with the pyramidal nitrogen atom, whereas in solu