14290-11-0

Usage

InChI:InChI=1/C15H16N2/c1-2-15(13-9-5-3-6-10-13)17-16-14-11-7-4-8-12-14/h3-12,16H,2H2,1H3

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 100-63-0 phenylhydrazine 

Downstream Products

• 10257-92-8 2-phenyl-3-methyl-1H-indole 
• 81323-40-2 N-Phenyl-N'-(1-amino-1-phenyl)propylhydrazine 
• 7189-06-2 (1,3-diphenyl-1H-pyrazol-4-yl)(phenyl)methanone 
• 78830-49-6 (1,3-diphenyl-1H-pyrazol-4-yl)(p-tolyl)methanone 
• 34672-83-8 ethoxy-2,2,6,6-tetramethylpiperidine-1 
• 65837-38-9 6-bromo-3-methyl-2-phenyl-indole 
• 39608-24-7 3-hydroperoxy-3-methyl-2-phenyl-3H-indole 
• 6011-26-3 2'-acetylbenzanilide 
• 131366-41-1 (1-Isocyanato-1-phenyl-propyl)-phenyl-diazene 
• 3558-28-9 1,3-dimethyl-2-phenyl-1H-indole 
• 81323-22-0 N-Phenyl-N'-(1-hydroxylamino-1-phenyl)propylhydrazine 
• 131366-31-9 5-Ethyl-2,5-diphenyl-[1,2,4]triazolidin-3-one 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of hydrazone derivatives as anti-proliferative agents

A series of triaryl-substituted hydrazones as structural acyclic prototypes were synthesized and screened for anti-proliferative activity against breast (Michigan cancer foundation-7 and MD Anderson metastatic breast-231) and uterine cancer (Ishikawa) cel

Synthesis of 4-Acylpyrazoles from Saturated Ketones and Hydrazones Featured with Multiple C(sp3)-H Bond Functionalization and C-C Bond Cleavage and Reorganization

In this paper, an efficient and convenient one-pot synthesis of diversely substituted 4-acylpyrazole derivatives via copper-catalyzed one-pot cascade reactions of saturated ketones with hydrazones is reported. Mechanistically, the formation of the title compounds involves the in situ formation of an enone intermediate through the dehydrogenation of a saturated ketone and the [2 + 3] cyclization of the enone with hydrazone followed by an aromatization-driven C-C bond cleavage and reorganization. To our knowledge, this is the first example in which the biologically and pharmaceutically important yet otherwise difficult-to-obtain 4-acylpyrazole derivatives are directly prepared from saturated ketones and hydrazones featured with multiple aliphatic C-H bond functionalization and C-C bond cleavage and reorganization. Compared with literature methods, this novel process has advantages such as simple and economical starting materials, a sustainable oxidant, excellent regioselectivity, and good efficiency.

TEMPO-mediated Aza-diels-alder reaction: Synthesis of tetrahydropyridazines using ketohydrazones and olefins

A novel, facile, and efficient method for the synthesis of tetrahydropyridazines by a one-pot tandem reaction of easily accessible ketohydrazones and olefins in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) has been successfully developed. The reaction involves the initial generation of azoalkenes from direct oxidative dehydrogenation of ketohydrazones using TEMPO as the commercially available oxidant, followed by a subsequent aza-Diels-Alder reaction with olefins.

The Fischer Indolisation of Cyclopropyl Phenyl Ketone and Cyclobutyl Phenyl Ketone Phenylhydrazones

Reaction of cyclopropyl phenyl ketone (3) with an equimolar quantity of phenylhydrazine (6) in boiling ethanolic hydrogen chloride under reflux affords 2,3,4,5-tetrahydro-2,6-diphenylpyridazine (23) and 3-(2-chloroethyl)-2-phenylindole (22). 8b-Methoxy-,

Addition of Dimethyl Acetylenedicarboxylate to 1,2,3-Trisubstituted Indoles having no Hydrogen on the Carbon Atom attached to C-2.

Addition of dimethyl acetylenedicarboxylate to seven 1,2,3-trisubstituted indoles having no hydrogen on the carbon atom attached to C-2, has yielded fourteen adducts which are mainly fused γ-lactones, but which include a new phenanthridine-dione, a novel spiro-dihydroindole, and a carbazole formed by the loss of methane.All structures were elucidated by spectroscopy.