14290-11-0Relevant articles and documents
Design, synthesis and biological evaluation of hydrazone derivatives as anti-proliferative agents
Shankar, Ravi,Rawal, Ravindra K.,Singh, Uma S.,Chaudhary, Preeti,Konwar, Rituraj,Hajela, Kanchan
, p. 1459 - 1468 (2017/06/05)
A series of triaryl-substituted hydrazones as structural acyclic prototypes were synthesized and screened for anti-proliferative activity against breast (Michigan cancer foundation-7 and MD Anderson metastatic breast-231) and uterine cancer (Ishikawa) cel
TEMPO-mediated Aza-diels-alder reaction: Synthesis of tetrahydropyridazines using ketohydrazones and olefins
Yang, Xiu-Long,Peng, Xie-Xue,Chen, Fei,Han, Bing
supporting information, p. 2070 - 2073 (2016/06/09)
A novel, facile, and efficient method for the synthesis of tetrahydropyridazines by a one-pot tandem reaction of easily accessible ketohydrazones and olefins in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) has been successfully developed. The reaction involves the initial generation of azoalkenes from direct oxidative dehydrogenation of ketohydrazones using TEMPO as the commercially available oxidant, followed by a subsequent aza-Diels-Alder reaction with olefins.
Addition of Dimethyl Acetylenedicarboxylate to 1,2,3-Trisubstituted Indoles having no Hydrogen on the Carbon Atom attached to C-2.
Letcher, Roy M.,Wai, John S. M.
, p. 514 - 536 (2007/10/02)
Addition of dimethyl acetylenedicarboxylate to seven 1,2,3-trisubstituted indoles having no hydrogen on the carbon atom attached to C-2, has yielded fourteen adducts which are mainly fused γ-lactones, but which include a new phenanthridine-dione, a novel spiro-dihydroindole, and a carbazole formed by the loss of methane.All structures were elucidated by spectroscopy.