142910-85-8

Basic information

• Product Name: (2-AMINO-1-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (2-AMINO-1-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-Butyl N-(2-amino-1-phenylethyl)carbamate;2-(Boc-amino)-2-phenylethylamine;CarbaMic acid, N-(2-aMino-1-phenylethyl)-, 1,1-diMethylethyl ester;α-(Boc-aMino)phenethylaMine;1,1-Dimethylethyl (2-amino-1-phenylethyl)carbamate
• CAS NO: 142910-85-8
• Molecular Formula: C13H20N2O2
• Molecular Weight: 236.3101
• Mol File: 142910-85-8.mol
• Article Data: 30

Chemical Properties

• Melting Point: 85-90°C
• Boiling Point: 372.2°Cat760mmHg
• Flash Point: 178.9°C
• Appearance: /
• Density: 1.066g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11?+-.0.46(Predicted)
• CAS DataBase Reference: (2-AMINO-1-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-1-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(142910-85-8)
• EPA Substance Registry System: (2-AMINO-1-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(142910-85-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 142910-85-8(Hazardous Substances Data)

Usage

Uses

Reactant for:Preparation of γ-lactams from carboxylic acids and amines via UDC (Ugi/De-BOC/Cyclize) strategy using isonitriles

InChI:InChI=1/C13H20N2O2/c1-13(2,3)17-12(16)15-11(9-14)10-7-5-4-6-8-10/h4-8,11H,9,14H2,1-3H3,(H,15,16)

Upstream product

• 312532-36-8 {(R)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 312532-37-9 {(S)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 20989-17-7 (2S)-2-phenylglycinol 
• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 
• 479687-23-5 1,2,3-oxathiazolidine-3-carboxylic acid, 4-phenyl 1,1-dimethylethyl ester-2,2-dioxide 
• 4248-19-5 tert-butyl carbazate 
• 100-52-7 benzaldehyde 
• 1242073-15-9 [(1S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-phenylethyl]carbamic acid 1,1-dimethylethyl ester 
• 941602-11-5 tert-butyl N-(2-nitro-1-phenylethyl)carbamate 
• 182160-14-1 2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-3-((S)-2-phenyl-aziridin-1-yl)-3H-quinazolin-4-one 
• 201730-84-9 3-((S)-2-Azido-2-phenyl-ethylamino)-2-((S)-1-hydroxy-2,2-dimethyl-propyl)-3H-quinazolin-4-one 
• 201730-83-8 3-((R)-2-Chloro-2-phenyl-ethylamino)-2-((S)-1-hydroxy-2,2-dimethyl-propyl)-3H-quinazolin-4-one 
• 137102-29-5 (S)-(+)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide 

Downstream Products

• 62779-70-8 (1S)-1-phenylethylene-1,2-diamine 
• 185137-29-5 (4S)-4-phenyl-1,3-thiazolidine-2-thione 
• 1589557-42-5 (R)-tert-butyl (2-(methylamino)-1-phenylethyl)carbamate 
• 1589557-40-3 (R)-tert-butyl (2-(benzylamino)-1-phenylethyl)carbamate 
• 1589557-41-4 (R)-tert-butyl (2-(benzyl(methyl)amino)-1-phenylethyl)carbamate 

Relevant articles and documents

Novel α-amino acid-derived phase-transfer catalyst application to a highly enantio- and diastereoselective nitro-Mannich reaction

New quaternary ammonium types of bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors derived from α-amino acids were readily prepared and found to be highly efficient in the asymmetric nitro-Mannich reactions of amidosulfones. Very broad substrate generality was observed, and the products were achieved in high enantio-/diastereoselectivities (90->99.9% ee, 90:10 to 92:8 dr). Compared with previous reports, the enantioselectivity of aliphatic amidosulfones has been improved to a high level (91-93% ee).

FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY

A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.

A Continuous-Flow, Two-Step, Metal-Free Process for the Synthesis of Differently Substituted Chiral 1,2-Diamino Derivatives

The enantioselective organocatalytic reduction of aryl-substituted nitroenamines was successfully performed under continuous-flow conditions. After a preliminary screening with a 10-μL microreactor, to establish the best reaction conditions, the reduction was scaled up in a 0.5-mL mesoreactor, without appreciable loss of enantioselectivity, that remained constantly higher than 90%. The in-flow nitro reduction was also accomplished, either by Raney nickel catalyzed hydrogenation or by a metal-free methodology based on the use of the very inexpensive and readily available reducing agent trichlorosilane. The final aim is to develop a two-step, continuous-flow process for the stereoselective, metal-free, catalytic synthesis of differently functionalized chiral 1,2-diamines.