1429253-97-3

Basic information

• Product Name: C₂₈H₂₆N₄O₂
• CAS NO: 1429253-97-3
• Molecular Weight: 450.54
• Mol File: 1429253-97-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₆N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₆N₄O₂(1429253-97-3)
• EPA Substance Registry System: C₂₈H₂₆N₄O₂(1429253-97-3)

Safety Data

• Hazardous Substances Data: 1429253-97-3(Hazardous Substances Data)

Upstream product

• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 591-31-1 3-methoxy-benzaldehyde 
• 1016408-05-1 6-chloro-N-(6-methylpyridin-2-yl)nicotinamide 
• 252061-94-2 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 57196-62-0 6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 942150-85-8 bis(6-methoxy-N-1,2,3,4-tetrahydroisoquinolinyl)methane 
• 59839-23-5 6-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 158984-83-9 N-tert-butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 164148-88-3 6-benzyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

SAR based design of nicotinamides as a novel class of androgen receptor antagonists for prostate cancer

Molecular knowledge of pure antagonism and systematic SAR study offered a direction for structural optimization of DIMN to provide nicotinamides as a novel series of AR antagonists. Nicotinamides with extended linear scaffold bearing sterically bulky alkoxy groups on isoquinoline end were synthesized for H12 displacement. AR binding affinity and molecular basis of antiandrogenic effect establish the optimized derivatives, 7au and 7bb, as promising candidates of second generation AR antagonists for advanced prostate cancer.