57196-62-0

Basic information

• Product Name: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
• Synonyms: 6-Methoxy-1,2,3,4-tetrahydrois;1,2,3,4-tetrahydro-6-methoxyisoquinoline hydrochloride;Isoquinoline, 1,2,3,4-tetrahydro-6-Methoxy-, hydrochloride;6-Methoxy-1,2,3,4-tetraihydroisoquinoline hydrochloride;6-METHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HCL;6-METHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;ISOQUINOLINE 1,2,3,4-TETRAHYDRO-6-METHOXY HCL SALT;Isoquinoline,1,2,3,4-tetrahydro-6-methoxy-,hydrochloride(1:1)
• CAS NO: 57196-62-0
• Molecular Formula: C₁₀H₁₃NO*ClH
• Molecular Weight: 199.68
• EINECS: -0
• Product Categories: API intermediates
• Mol File: 57196-62-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 230-232.5°C
• Boiling Point: 283.6 °C at 760 mmHg
• Flash Point: 109.2 °C
• Appearance: /
• Vapor Pressure: 0.00313mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(57196-62-0)
• EPA Substance Registry System: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(57196-62-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-51
• HazardClass: IRRITANT
• Hazardous Substances Data: 57196-62-0(Hazardous Substances Data)

Usage

General Description

6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is an organic compound that falls under the chemical class of tetrahydroisoquinolines, which are heterocyclic compounds comprising of a benzene attached to an isoquinoline. It carries the methoxy functional group on the aromatic ring. Many of these types of compounds play significant roles in the field of medicinal chemistry and have been synthesized for their pharmaceutical properties. The specific use, toxicity, and biological activity of 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride can vary significantly and is greatly influenced by its molecular and structural characteristics.

InChI:InChI=1/C10H13NO.ClH/c1-12-10-3-2-9-7-11-5-4-8(9)6-10;/h2-3,6,11H,4-5,7H2,1H3;1H

Upstream product

• 50-00-0 formaldehyd 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 
• 591-31-1 3-methoxy-benzaldehyde 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 55-81-2 4-Methoxyphenethylamine 
• 110339-54-3 N-[2-(3-methoxy-phenyl)-ethyl]-formamide 
• 942150-85-8 bis(6-methoxy-N-1,2,3,4-tetrahydroisoquinolinyl)methane 
• 14446-29-8 6-Methoxy-3,4-dihydroisoquinoline 

Downstream Products

• 1429253-97-3 C₂₈H₂₆N₄O₂ 
• 1429253-99-5 C₂₃H₂₃N₃O₃ 
• 1429254-04-5 C₂₄H₂₅N₃O₃ 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 158984-83-9 N-tert-butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 164148-88-3 6-benzyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 630407-52-2 6-ethoxy-1,2,3,4-tetrahydro-isoquinoline 
• 252061-94-2 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline 
• 94085-74-2 6-hydroxy-2-(3-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline 
• 1064199-05-8 2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline 
• 1064200-01-6 2-(3,5-dimethoxybenzoyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 1064205-99-7 2-(2-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol 
• 860436-57-3 tert-butyl 6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1394241-60-1 C₁₇H₁₇NO₅S 

Relevant articles and documents

Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation

6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line.

PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES

The present invention is directed to a process for the synthesis of substituted-1,2,3,4-tetrahydroisoquinoline derivatives, useful as intermediates in the synthesis of pharmaceutical agents.

5-HT7 receptor antagonists

The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds of the formula I: to processes of preparation of such compounds, to pharm