1430234-67-5

Basic information

• Product Name: C₂₈H₃₀N₆O₃
• Synonyms: C₂₈H₃₀N₆O₃
• CAS NO: 1430234-67-5
• Molecular Weight: 498.585
• Mol File: 1430234-67-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₀N₆O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₀N₆O₃(1430234-67-5)
• EPA Substance Registry System: C₂₈H₃₀N₆O₃(1430234-67-5)

Safety Data

• Hazardous Substances Data: 1430234-67-5(Hazardous Substances Data)

Upstream product

• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 
• 100-02-7 4-nitro-phenol 
• 1186620-39-2 4-methoxy-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid 
• 62424-88-8 N,N-dimethyl-3-(4-aminophenoxy)propylamine 
• 1430234-78-8 4-methoxy-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester 
• 1430234-77-7 3-guanidino-4-methoxybenzoic acid ethyl ester nitrate 
• 16357-44-1 3-amino-4-methoxy-benzoic acid ethyl ester 
• 2840-26-8 3-amino-4-methoxybenzoic acid 

Relevant articles and documents

Design, synthesis and biological activities of Nilotinib derivates as antitumor agents

A novel class of Nilotinib derivatives, B1-B20, were synthesized in high yields using various substituted anilines. All the title compounds were evaluated for their inhibitory activities against Bcr-Abl and antiproliferative effects on human leukemia cell (K562). The pharmacological results indicated that some compounds exhibited promising anticancer activity. In particular, compound B14 containing tertiary amine side chain exhibited Bcr-Abl inhibitory activity similar to that of Nilotinib. It was suggested that the introduction of the tertiary amine moiety could improve Bcr-Abl inhibitory activity and antitumor effects.