62424-88-8

Basic information

• Product Name: 4-[3-(DIMETHYLAMINO)PROPOXY]ANILINE
• Synonyms: 4-[3-(DIMETHYLAMINO)PROPOXY]ANILINE;4-(3-DIMETHYLAMINO-PROPOXY)-PHENYLAMINE;4-[3-(N,N-Dimethylamino)propoxy]aniline;Benzenamine, 4-[3-(dimethylamino)propoxy]-
• CAS NO: 62424-88-8
• Molecular Formula: C₁₁H₁₈N₂O
• Molecular Weight: 194.27342
• Mol File: 62424-88-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[3-(DIMETHYLAMINO)PROPOXY]ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3-(DIMETHYLAMINO)PROPOXY]ANILINE(62424-88-8)
• EPA Substance Registry System: 4-[3-(DIMETHYLAMINO)PROPOXY]ANILINE(62424-88-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 62424-88-8(Hazardous Substances Data)

Usage

General Description

4-[3-(Dimethylamino)propoxy]aniline, also known as DMAPA, is an organic compound used in the production of certain dyes and pharmaceuticals. It is a clear, colorless to light yellow liquid with a slightly amine-like odor. DMAPA is classified as a tertiary amine, and it contains a dimethylamino group attached to a propoxy side chain and an aniline ring. It is primarily used as an intermediate in the synthesis of dyes, pigments, and certain pharmaceutical products. DMAPA can also serve as a catalyst for certain reactions and as a stabilizer in the production of polymers. As with any chemical, proper handling and safety precautions should be observed when working with DMAPA to prevent exposure and potential health hazards.

Upstream product

• 100-02-7 4-nitro-phenol 
• 79096-54-1 1-(3-Chloropropoxy)-4-nitrobenzene 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 1124-31-8 potassium 4-nitrophenolate 
• 123-30-8 4-amino-phenol 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 

Downstream Products

• 1247824-86-7 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-[4-(3-dimethylamino-propoxy)phenyl]-4-nitrothiophene-2-carboxamide 
• 1247825-27-9 4-cyano-5-[(3,5-dichloropyridin-4-yl)thio]-N-{4-[3-(dimethylamino)propoxy]phenyl} thiophene-2-carboxamide 
• 1430234-67-5 C₂₈H₃₀N₆O₃ 
• 62424-98-0 1-Butyl-6-[3-(dimethylamino)propoxy]-3,4-dihydro-4-phenyl-2(1H)-quinolinone, oxalate salt 
• 62424-96-8 6-[3-(Dimethylamino)propoxy]-3,4-dihydro-1-methyl-4-phenyl-2(1H)-quinolinone, fumarate salt 
• 62424-94-6 6-[3-(dimethylamino)propoxy]-1-ethyl-3,4-dihydro-4-phenyl-2(1H)-quinolinone, hydrochloride 
• 62424-90-2 6-[3-(dimethylamino)-propoxy]-3,4-dihydro-4-phenyl-2(1H)-quinolinone 
• 1436865-02-9 C₂₀H₂₇N₃O₂ 
• 280580-97-4 5-Bromo-2-{4-[3-(N,N-dimethylamino)propoxy]anilino}-4-[(6-methylpyrid-2-yl)amino]pyrimidine 

Relevant articles and documents

With anti-tumor activity of a biphenyl amide compound and its preparation method and application

The invention discloses a biphenyl amide compound with antitumor activity as well as a preparation method and application thereof. The structural formula of the compound is shown in the specification, wherein in the structural formula, R1 is hydrogen or halogen; R2 is alkoxy with carbon number of 1-4; the terminal of R2 is replaced by tert-amido; R2 is linked to the para-position of amide via an oxygen atom. The compound has good tumor cell inhibiting activity in vitro and can be used for preparing antitumor drugs, especially anti-hepatoma drugs and anti-breast cancer drugs. The preparation method of the biphenyl amide compound, provided by the invention, has the advantages that the raw materials are accessible, the reaction conditions are mild, the reaction process is simple to operate, and the used reagent is cheap.

Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors

A series of pyridin-3-yl pyrimidines was synthesized and evaluated for their Bcr-Abl inhibitory and anticancer activity. The preliminary results indicated that some compounds were promising anticancer agents. Compounds A2, A8, and A9 exhibited potent Bcr-Abl inhibitory activity, suggesting that aniline containing halogen substituents might be important for biological activity. Molecular docking was carried out to investigate the binding mode of them with Bcr-Abl. Details of synthesis and SAR studies of these compounds are described. A series of phenylaminopyrimidines was designed and synthesized as potent Bcr-Abl inhibitors. The screening of these rationally designed compounds for antitumor activity had identified three candidate leads which could be further optimized to improve the anticancer activities.

INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER

The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.