1430836-24-0

Basic information

• Product Name: 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide
• Synonyms: 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide
• CAS NO: 1430836-24-0
• Molecular Weight: 490.31
• Mol File: 1430836-24-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide(1430836-24-0)
• EPA Substance Registry System: 2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide(1430836-24-0)

Safety Data

• Hazardous Substances Data: 1430836-24-0(Hazardous Substances Data)

Upstream product

• 75822-54-7 5’-bromo-1‘,2’-dihydrospiro[1,3-dioxolane-2,3’-indole]-2’-one 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 66475-83-0 N-(4-bromophenyl)-2-(hydroxyimino) acetamide 
• 106-40-1 4-bromo-aniline 
• 331267-94-8 C₁₂H₁₀BrNO₅ 
• 1446416-14-3 C₂₂H₂₁BrN₂O₆ 
• 133189-11-4 methyl-2-(5′-bromo-2′-oxospiro[[1,3]dioxolane-2,3′-indoline]-1′-yl) acetate 

Relevant articles and documents

Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN)

Aminopeptidase N (APN/CD13), as a zinc-containing ectoenzyme, plays a critical role in the process of tumor angiogenesis, invasion and metastasis. Through the docking-based virtual screening of chemical databases and the further activity assay, we discovered that compound 10c exhibits potent and selective inhibitory ability towards APN. In addition, a series of indoline-2,3-dione derivates have been designed and synthesized as APN inhibitors. The results of preliminary activity evaluation showed that compound 12a (IC50 = 0.074 ± 0.0026 μM) exhibited the best inhibitory activity against APN, which could be used for further anticancer agent research.