1431323-88-4

Basic information

• Product Name: 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one
• Synonyms: 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one
• CAS NO: 1431323-88-4
• Molecular Weight: 495.411
• Mol File: 1431323-88-4.mol

Chemical Properties

• CAS DataBase Reference: 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one(1431323-88-4)
• EPA Substance Registry System: 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one(1431323-88-4)

Safety Data

• Hazardous Substances Data: 1431323-88-4(Hazardous Substances Data)

Upstream product

• 74840-34-9 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 
• 16153-81-4 4-(4-Methyl-piperazino)-anilin 
• 1431323-90-8 6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one 
• 397308-78-0 4-hydroxy-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 
• 1431323-75-9 1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone 
• 307531-80-2 (2,6-dichlorobenzyl)zinc(II) chloride 
• 55084-66-7 4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride 
• 1431323-89-5 2-(2,6-dichlorophenyl)-1-(4-(methylamino)-2-(methylthio)pyrimidin-5-yl)ethanone 
• 19572-13-5 8-methyl-2-(methylthio)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 625106-58-3 ethyl 4-((3-ethoxy-3-oxopropyl)(methyl)amino)-2-(methylthio)pyrimidine-5-carboxylate 

Relevant articles and documents

Investigation of biaryl heterocycles as inhibitors of Wee1 kinase

In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure?activ

PHARMACEUTICAL COMPOUNDS

The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

PYRIDOPYRIMIDINONE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.