1431868-05-1

Basic information

• Product Name: C₂₁H₂₃I₂NO₆
• Synonyms: C₂₁H₂₃I₂NO₆
• CAS NO: 1431868-05-1
• Molecular Weight: 639.226
• Mol File: 1431868-05-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₃I₂NO₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₃I₂NO₆(1431868-05-1)
• EPA Substance Registry System: C₂₁H₂₃I₂NO₆(1431868-05-1)

Safety Data

• Hazardous Substances Data: 1431868-05-1(Hazardous Substances Data)

Upstream product

• 60-18-4 L-tyrosine 
• 1080-06-4 L-Tyr-OMe 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 128781-80-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate 
• 1016161-91-3 C₃₀H₄₃I₂NO₆Si 

Downstream Products

• 88404-22-2 (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid 
• 51-48-9 L-thyroxine 
• 178877-78-6 C₂₀H₂₁I₂NO₆ 
• 1041-01-6 3,5-diiodo-L-thyronine 

Relevant articles and documents

The synthesis of 13C9-15N-labeled 3,5-diiodothyronine and thyroxine

Thyroid hormones undergo extensive metabolism to regulate hormone activity. A labeled thyroid hormone would be useful to track hormone metabolism through various pathways. While radiolabeled thyroid hormones have been synthesized and used for in vivo studies, a stable isotope labeled form of thyroid hormone is required for studying thyroid hormone metabolism by LC-MS/MS, an analytical technique that has certain advantages without the complications of radioactivity. Here we report the synthesis of 13C9- 15N-T2 and 13C9-15N- T4, two labeled thyroid hormone derivatives suitable for in vivo LC-MS/MS studies. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.