88404-22-2

Usage

Uses

Used in Analytical Chemistry:
N-(tert-Butyloxy)carbonyl-L-thyroxine is used as a key component in the preparation of thyroxine (T4) analogue biosensors. These biosensors are designed for use on the BIAcore surface plasmon resonance instrument, a powerful analytical tool that enables real-time monitoring of biomolecular interactions.
Used in Biomedical Research:
In biomedical research, N-(tert-Butyloxy)carbonyl-L-thyroxine-based biosensors can be employed to study the binding kinetics and affinity of thyroxine and its analogues to specific receptors or other biomolecules. This information is crucial for understanding the mechanisms of thyroid hormone action and for the development of new therapeutic agents targeting the thyroid system.
Used in Pharmaceutical Industry:
The development of thyroxine analogue biosensors using N-(tert-Butyloxy)carbonyl-L-thyroxine can also benefit the pharmaceutical industry by providing a means to screen and optimize compounds with potential therapeutic effects on the thyroid gland. This can lead to the discovery of novel drugs for the treatment of thyroid-related disorders, such as hypothyroidism and hyperthyroidism.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 51-48-9 L-thyroxine 
• 1431868-09-5 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate 
• 60-18-4 L-tyrosine 
• 1080-06-4 L-Tyr-OMe 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 128781-80-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate 
• 1016161-91-3 C₃₀H₄₃I₂NO₆Si 
• 300-30-1 thyroxine 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 1431868-05-1 C₂₁H₂₃I₂NO₆ 

Relevant academic research and scientific papers

Novel derivatives of thyroid hormone and use of thereof

The present invention relates to: a thyroid hormone derivative or a pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of diseases of the brain and nervous system due to dopamine deficiency, containing the same as an active ingredient; and a method for treating diseases of the brain and nervous system caused by dopamine deficiency. The thyroid hormone derivative according to the present invention can promote the differentiation of neural progenitors into dopamine neurons like thyroid hormones, while lowering the risk of hyperthyroidism by repeated administration, and thus, can be useful for the prevention and treatment of diseases of the brain and nervous system due to dopamine deficiency, including Parkinsonandprime;s disease. A compound or a pharmaceutically acceptable salt thereof is represented by chemical formula 1.COPYRIGHT KIPO 2021

Novel derivatives of thyroid hormone and use of thereof

The present invention relates to: a thyroid hormone derivative or a pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of diseases of the brain and nervous system due to dopamine deficiency, containing the same as an active ingredient; and a method for treating diseases of the brain and nervous system caused by dopamine deficiency. The thyroid hormone derivative according to the present invention can promote the differentiation of neural progenitors into dopamine neurons like thyroid hormones, while lowering the risk of hyperthyroidism by repeated administration, and thus, can be useful for the prevention and treatment of diseases of the brain and nervous system due to dopamine deficiency, including Parkinsonandprime;s disease. A compound or a pharmaceutically acceptable salt thereof is represented by chemical formula 1.COPYRIGHT KIPO 2020

Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof

Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.

Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof

Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Nanoparticle forms of thyroid hormone or thyroid hormone analogs as well as uses thereof are also disclosed.

Uses of formulations of thyroid hormone antagonists and nanoparticulate forms thereof to increase chemosensivity and radiosensitivity in tumor or cancer cells

Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone antagonists and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or radioresistant tumor or cancer cells using thyroid hormone antagonists and/or nanoparticulate or polymeric forms thereof.

The synthesis of 13C9-15N-labeled 3,5-diiodothyronine and thyroxine

Thyroid hormones undergo extensive metabolism to regulate hormone activity. A labeled thyroid hormone would be useful to track hormone metabolism through various pathways. While radiolabeled thyroid hormones have been synthesized and used for in vivo studies, a stable isotope labeled form of thyroid hormone is required for studying thyroid hormone metabolism by LC-MS/MS, an analytical technique that has certain advantages without the complications of radioactivity. Here we report the synthesis of 13C9- 15N-T2 and 13C9-15N- T4, two labeled thyroid hormone derivatives suitable for in vivo LC-MS/MS studies. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.

USES OF FORMULATIONS OF THYROID HORMONE ANALOGS AND NANOPARTICULATE FORMS THEREOF TO INCREASE CHEMOSENSIVITY AND RADIOSENSITIVITY IN TUMOR OR CANCER CELLS

Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or radioresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof.

Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmaco

NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE ANALOGS, ANTAGONISTS, AND FORMULATIONS THEREOF

Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit a

Insulin derivatives and synthesis thereof

Derivatives of insulin are described which are conjugated to thyroid hormones. The thyroid hormone is, for instance, D-thyroxine (3,3′,5,5′-tetraiodo-D-thyronine). Other analogues are described in which a spacer having a alkanediyl chain at least eleven c