1431978-53-8

Basic information

• Product Name: 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile
• Synonyms: 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile
• CAS NO: 1431978-53-8
• Molecular Weight: 376.36
• Mol File: 1431978-53-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile(1431978-53-8)
• EPA Substance Registry System: 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile(1431978-53-8)

Safety Data

• Hazardous Substances Data: 1431978-53-8(Hazardous Substances Data)

Upstream product

• 34846-44-1 3-Bromomethylthiophene 
• 1431978-52-7 2-isopropyl-3-methyl-2-(5-(o-tolyl)thiophen-3-yl)butanenitrile 
• 1431978-51-6 2-isopropyl-3-methyl-2-(thiophen-3-yl)butanenitrile 
• 13781-53-8 (thiophen-3-yl)acetonitrile 
• 616-44-4 3-Methylthiophene 

Relevant articles and documents

Intramolecular PdII-catalyzed dehydrogenative C(sp 3)-C(sp2) coupling: An alternative to Pd 0-catalyzed C(sp3)-H arylation from aryl halides?

The synthesis of fused thiophene-cyclopentanes by PdII-catalyzed dehydrogenative C(sp2)-H/C(sp3)-H coupling is described. This reaction shows interesting chemo- and diastereoselectivity, however a direct comparison showed that it is yet much less efficient than the two-step sequence composed of electrophilic halogenation and Pd0-catalyzed C(sp3)-H arylation.