1432059-83-0

Upstream product

• 1432059-19-2 C₂₂H₂₀Cl₂N₂O₃ 
• 1432059-82-9 tert-butyl (E)-(3-cyano-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindolin-3-yl)carbamate 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 40950-94-5 ethyl (E)-3-(3,4-dichloro-phenyl)-2-propenoate 
• 148775-22-8 3-(3,4-dichlorophenyl)-prop-2-en-1-ol 
• 149946-25-8 (E)-4-(3-bromoprop-1-en-1-yl)-1,2-dichlorobenzene 
• 945736-71-0 (E)-1-(3-(3,4-dichlorophenyl)allyl)indoline-2,3-dione 
• 7677-24-9 trimethylsilyl cyanide 

Relevant academic research and scientific papers

Catalytic Enantioselective Strecker Reaction of Isatin-Derived N-Unsubstituted Ketimines

A catalytic enantioselective Strecker reaction of isatin-derived N-unsubstituted ketimines directly afforded the N-unprotected α-aminonitriles with a tetrasubstituted carbon stereocenter in up to 99% ee without requiring protection/deprotection steps. One-pot Strecker reactions from the parent carbonyl compounds were also realized with comparable yields and enantioselectivities. Direct transformations of the N-unprotected α-aminonitrile products streamlined the synthesis of unnatural amino acid derivatives and achieved the shortest one-pot stereoselective routes to a biologically active compound reported to date.

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.