143426-36-2Relevant academic research and scientific papers
Development of an acid ceramidase activity-based probe
Ouairy, Cécile M. J.,Ferraz, Maria J.,Boot, Rolf G.,Baggelaar, Marc P.,Van Der Stelt, Mario,Appelman, Monique,Van Der Marel, Gijsbert A.,Florea, Bogdan I.,Aerts, Johannes M. F. G.,Overkleeft, Herman S.
supporting information, p. 6161 - 6163 (2015/04/14)
Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.
Chemoenzymatic Approach to the Synthesis of the Antiviral Agents Penciclovir and Famciclovir in Isotopically Chiral Labelled Form
Sime, John T.,Barnes, Roger D.,Elson, Stephen W.,Jarvest, Richard L.,O'Toole, Kevin J.
, p. 1653 - 1658 (2007/10/02)
The antiviral agents penciclovir and famciclovir have been synthesised in isotopically chiral form.The synthesis of (+)-methyl 4-benzyloxy-2-(hydroxymethyl)butanoate 12a by use of enzymatic hydrolysis catalysed by the lipase from Candida cylindrac
