88481-68-9

Upstream product

• 100-39-0 benzyl bromide 
• 1339946-61-0 (S)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)-pent-4-en-1-ol 
• 88481-66-7 (2S,3S)-3-(benzyloxymethyl)-hex-5-ene-1,2-diol 
• 59499-13-7 2-Chlorocarbonyl-pent-4-enoic acid ethyl ester 
• 2985-38-8 2-(ethoxycarbonyl)-4-pentenoic acid 
• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 
• 1231913-19-1 (S)-2-(1,4-dioxaspiro[4.5]decan-2-yl)-pent-4-enal 
• 176541-03-0 Acetic acid (R)-2-(2-methoxy-ethoxymethoxymethyl)-pent-4-enyl ester 
• 176541-04-1 (S)-2-(2-Methoxy-ethoxymethoxymethyl)-pent-4-en-1-ol 
• 117935-56-5 R-(+)-2-(hydroxymethyl)-4-pentenyl acetate 
• 42201-43-4 2-allyl-1,3-propanediol 
• 176540-99-1 [(S)-2-(2-Methoxy-ethoxymethoxymethyl)-pent-4-enyloxymethyl]-benzene 
• 88481-65-6 (4S,5S)-5-Allyl-4-hydroxymethyl-2-phenyl-1,3-dioxan 

Downstream Products

• 69778-58-1 (E)-(S)-4-Ethyl-6-hydroxymethyl-1-(4-methoxy-phenyl)-nona-4,8-dien-1-one 
• 143426-37-3 (S)-2-benzyloxymethylbutan-4-olide 
• 143426-36-2 (S)-methyl 2-((benzyloxy)methyl)pent-4-enoate 
• 137063-09-3 Toluene-4-sulfonic acid (S)-2-benzyloxymethyl-4-oxo-butyl ester 
• 137063-10-6 (R)-1-<3-(benzyloxymethyl)pyrrolidin-1-yl>cytosine 
• 137063-08-2 (S)-2-benzyloxymethylpent-4-enyl toluene-p-sulphonate 

Relevant academic research and scientific papers

Hydrogen-Bonding Assisted Catalytic Kinetic Resolution of Acyclic β-Hydroxy Amides

Enantioenriched acyclic α-substituted β-hydroxy amides are valuable compounds in chemical, material and medicinal sciences, but their enantioselective synthesis remains challenging. A catalytic kinetic resolution (KR) of such amides with selectivity factor(s) up to >200 is developed via enantioselective acylation of primary alcohol with N-heterocyclic carbene. An enhanced selectivity for the catalytic KR process is realized using cyclic tertiary amine as base additive. Diastereomeric transition state models for the process are proposed to rationalize the origin of enantioselectivity.

A stereodivergent approach to carbahexofuranoses: Synthesis of carba-α-d-glucofuranose, carba-β-d-altrofuranose, carba-α-d-allofuranose, carba-β-d-idofuranose, carba-α-d- galactofuranose and carba-β-d-talofuranose

A stereodivergent route, starting from d-glyceraldehyde derivative, employing Wittig olefination-Claisen rearrangement protocol is reported for the synthesis of six novel carbahexofuranoses - carba-α-d-glucofuranose, carba-β-d-altrofuranose, carba-α-d-all

USE OF (R)-PENCICLOVIR TRIPHOSPHATE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF VIRAL DISEASES

A method of treatment of: i) HIV-1 infections in mammals, including humans; or ii) HBV infections in mammals, including humans; which method comprises the administration to the human in need of such treatment, an effective amount of the (R)-enantiomer of the triphosphate of a compound of formula (A) or a pharmaceutically acceptable salt thereof; and compounds for use in the method.

Asymmetric Bis(alkoxycarbonylation) Reaction of Homoallylic Alcohols Catalyzed by Palladium in the Presence of Cu(I) Triflate Using the Chiral Bioxazoline Ligand

Palladium-catalyzed asymmetric intra- and intermolecular bis(alkoxycarbonylation) reactions of homoallylic alcohols in the presence of copper(I) triflate were achieved by using the chiral bioxazoline ligand, (S,S)-4,4′-dibenzyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, under normal pressure of carbon monoxide and oxygen at 25°C to give the corresponding optically active γ-butyrolactones in 19 - 65% ee.

Enantiomerically Pure Building Blocks for Syntheses from Branched Malates

Isocitric acid lactone (13) and the chiral building blocks (2S,3R)-4-bromo-1,2-epoxy-3-methyl-butane (21), cis- and trans 2,3-epoxy-2-methylsuccinates (23, 24), and the singly protected (2R)-2-methyl-, -2-allyl- and -2-benzyl-1,3-propanediols (32a, b, c)