1434643-33-0

Upstream product

• 43088-42-2 2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester 
• 4815-30-9 diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate 
• 1434643-28-3 tert-butyl 2-methyl-2-(5-methyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine-3(2H)-yl)propanoate 
• 1434643-23-8 3-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothiopheno[2,3-d]pyrimidine-6-carboxylic acid 
• 1434643-18-1 ethyl 3-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylic acid 
• 1434643-13-6 diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate 
• 1434655-18-1 tert-butyl 2-isocyanato-2-methylpropanoate 
• 4512-32-7 H-Aib-OtBu 

Downstream Products

• 1434648-09-5 C₂₃H₂₅BrN₂O₅S 
• 1434643-89-6 C₂₅H₃₁BrN₂O₄S 
• 1434650-54-0 C₃₃H₄₆BrN₃O₇SSi 
• 1434651-37-2 C₂₉H₄₁BrN₂O₆SSi 
• 1434651-42-9 C₃₂H₄₃N₃O₇SSi 
• 1434651-66-7 C₃₀H₄₃BrN₂O₆SSi 
• 1434651-71-4 C₂₄H₂₉BrN₂O₆S 
• 1434632-94-6 2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid 
• 1434632-88-8 (S)-2-methyl-2-(5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1-(2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl)-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)propanoic acid 
• 1434631-76-1 methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid 
• 1434638-59-1 2-[1-[(2R)-2-[(3-hydroxyazetidin-1-yl)carbonyloxy]-2-phenylethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid 
• 1434634-21-5 2-[1-[(2R)-2-(2-methoxyphenyl)-2-(propan-2-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid 
• 1434632-62-8 2-[1-[2-(2-ethylphenyl)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid 
• 1434643-95-4 C₂₈H₃₃N₃O₅S 

Relevant academic research and scientific papers

Preparation method of acetyl-coA carboxylase inhibitor

The invention relates to the field of pharmacy, and particularly relates to a preparation method of an acetyl-coA carboxylase inhibitor. The method comprises the following steps of firstly enabling 2-(6-halo-5-methyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimid-3(2H)-yl)-2-tert-butyl methacrylate (II) to react with halogenated o-methoxyacetophenone, then hydrolyzing, protecting a carboxyl group witha silicon group, reducing, halogenating, subsequently substituting a halogen atom by alcohol to obtain a key intermediate 2-(6-halo-1-(2-(2-methoxyphenyl)-2-alkoxy)-ethyl)-5-methyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimid-3(2H)-yl)-2-silicon methacrylate (VIII), and finally preparing a target compound through Stille coupling and the removal of a protecting group of the silicon group. The method is a few in side reaction, low in cost, simple and convenient to operate and suitable for industrialized production.

THIENOPYRIMIDINE DERIVATIVE AND USE THEREOF IN MEDICINE

The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.

SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF

The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.

Preparation method of ACC (acetyl-coA carboxylase) inhibitor drug key intermediate

The invention relates to a method of synthesizing an ACC (acetyl-coA carboxylase) inhibitor drug key intermediate and belongs to the field of chemical synthesis. A target compound is mainly prepared by modifying a starting material and performing Gewald aminothiophene reaction, amide synthesis, closed-loop reaction, bromination and other reactions, the step of alkali hydrolysis of ethyl formate group is not required, next decarboxylation reaction is not required either, the reaction process is shortened, and the preparation method has the advantages of good path stability and safety, low cost, low price and good accessibility of materials, high yield and the like.

PYRAZOLE ACC INHIBITORS AND USES THEREOF

The invention provides pyrazole compounds of formula I inhibiting Acetyl CoA Carboxylase (ACC), compositions and uses thereof for the treatment of obesity or as fungicides.

ACC INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.