1434774-76-1

Basic information

• Product Name: ethyl (E)-6-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methylhex-4-enoate
• Synonyms: ethyl (E)-6-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methylhex-4-enoate
• CAS NO: 1434774-76-1
• Molecular Weight: 426.628
• Mol File: 1434774-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (E)-6-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methylhex-4-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (E)-6-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methylhex-4-enoate(1434774-76-1)
• EPA Substance Registry System: ethyl (E)-6-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methylhex-4-enoate(1434774-76-1)

Safety Data

• Hazardous Substances Data: 1434774-76-1(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 186953-23-1 (E)-4-((tert-butyldiphenylsilyl)oxy)-2-methylbut-2-enal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 188263-82-3 1-((tert-butyldiphenylsilyl)oxy)-3-methyl-2-butene 
• 556-82-1 3-methyl-2-buten-1-ol 
• 189437-81-8 (E)-4-(tert-butyldiphenylsilanyloxy)-2-methyl-but-2-en-1-ol 

Downstream Products

• 1434774-80-7 C₃₁H₄₈O₄Si₂ 

Relevant articles and documents

The formal total synthesis of FR252921-An immunosuppressant

The formal total synthesis of FR252921 is described. The key steps include the preparation of three fragments starting from 1,4-butanediol, (R)-malic acid, and prenol, respectively, followed by two consecutive peptide couplings of the three fragments. Other key steps involve an allene-type rearrangement or enyne isomerization to install the triene moiety, a Seebach methylation, a Julia olefination to construct the trisubstituted diene unit, and an enzymatic resolution strategy to generate the C-18 stereocenter.