1435-04-7

Usage

Uses

Used in Organic Synthesis:
Phenol, 2-[(2-thienylmethylene)amino]is utilized as a key intermediate in organic synthesis for the creation of various new compounds. Its unique structure allows it to react with a range of reagents, expanding the scope of chemical reactions and the types of molecules that can be synthesized.
Used in Pharmaceutical Development:
In the pharmaceutical industry, Phenol, 2-[(2-thienylmethylene)amino]is employed as a building block for the development of new drugs. The thienylmethylene group contributes specific properties that can enhance the pharmacological activity of the resulting compounds, making it an important component in the design and synthesis of potential therapeutic agents.
Used in Chemical Research:
Phenol, 2-[(2-thienylmethylene)amino]is also used in chemical research to explore its reactivity and potential applications. Researchers leverage its unique structure to investigate new reaction pathways and mechanisms, contributing to the advancement of chemical knowledge and the discovery of innovative applications in various fields.

InChI:InChI=1/C11H9NOS/c13-11-6-2-1-5-10(11)12-8-9-4-3-7-14-9/h1-8,13H/b12-8+

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 95-55-6 2-amino-phenol 

Downstream Products

• 23999-63-5 2-thiophen-2-yl-benzooxazole 
• 71173-45-0 2-Thiophen-2-yl-2,3-dihydro-benzooxazole 
• 1000026-15-2 2-((1R,2R)-2-phenyl-1-(thiophen-2-yl)-but-3-enylamino)phenol 

Relevant academic research and scientific papers

Characterization, and crystal structure of thiophenyl-2-methylidene-2- aminophenol

The Schiff base thiophenyl-2-methylidene-2-aminophenol (ImineOH) is obtained from a stoichiometric mixture of 2-thiophenecarboxaldehyde and 2-aminophenol in ethanol under reflux at 90 C. Its crystal structure is determined by single crystal X-ray diffract

Base-Free and Catalyst-Free Synthesis of Functionalized Dihydrobenzoxazoles via Vinylogous Carbonate to Carbamate Rearrangement

An unexpected, catalyst-free, and base-free intramolecular cyclization of N-aryloxyacrylate aldimines, under thermal conditions leading to the synthesis of functionalized dihydrobenzoxazoles, is reported. The reaction features a unique rearrangement of vi

ELECTROLUMINESCENT DEVICE USING AZOMETHINE-LITHIUM-COMPLEX AS ELECTRON INJECTION LAYER

In OLEDs, improved efficiency is obtained by compounds which can form inter alia electron injection layers of the formula (I) wherein R1 is a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with one or mor

Highly enantioselective imine cinnamylation with a remarkable diastereochemical switch

The first general method for the enantioselective cinnamylation of aldimines is reported. The method utilizes a simple chiral cinnamylsilane reagent and is characterized by experimental simplicity and extraordinarily high levels of enantioselectivity. Fur

STUDIES ON METAL COMLEXES OF 2-(o-HYDROXYPHENYLIMINOMETHYL)THIOPHENE AND 2-(o-HYDROXYPHENYLIMINOMETHYL)PYRROLE

The synthesis of Zn, Cd and Ni complexes of Schiff bases 2-(o-hydroxyphenyliminomethyl)thiophene and 2-(o-hydroxyphenyliminomethyl)pyrrole is described.The nature, composition and structure of the isolated solid complexes have been elucidated by elemental

Photochemical and Thermal Reactions of Aromatic Schiff Bases

The photochemical and thermal reactions of aromatic Schiff bases (SB) prepared from o-aminophenol and aldehydes and from o-aminophenol and ketones are compared.All SB's are converted by light into the corresponding benzoxazolines.For the SB's derived from aldehydes, benzoxazoline formation is a prerequisite to convert them by a second photon into benzoxazoles.In some cases oxygen is not required for this second reaction step.SB's derived from ketones are converted into benzoxazoles by the absorption of just one photon, but only in the presence of oxygen and only if the aliphatic residue R1 of the N=C(R1R2) bridge contains at least two carbon atoms.A radical mechanism is proposed for this reaction.Benzoxazine formation is observed in some cases as a thermal side reaction.The photochemical reactions of the latter were also investigated.