143541-34-8

Upstream product

• 591-51-5 phenyllithium 
• 140860-85-1 2-fluoro-5-phenyl-3-(trifluoromethyl)furan 
• 114192-88-0 (E)-4,4,4-trifluoro-1-phenylbut-2-en-1-one 
• 98-88-4 benzoyl chloride 
• 35443-84-6 4,4,4-trifluoro-1-phenyl-3-(trifluoromethyl)but-2-en-1-one 
• 140860-79-3 4,4-difluoro-1-phenyl-3-(trifluoromethyl)but-3-en-1-one 

Relevant academic research and scientific papers

Transition-Metal-Free Synthesis of Trifluoromethylated Furans via a Bu3P-Mediated Tandem Acylation-Wittig Reaction

A highly efficient nucleophilic addition- O -acylation-intramolecular Wittig reaction of β-trifluoromethyl α,β-enones is disclosed. This strategy features mild reaction conditions and provides a practical transition-metal-free method to a set of biologically significant trifluoromethylated furans in high yields with diverse functional groups.

Partially fluorinated heterocycles from 4,4-bis(trifluoromethyl)-hetero-1, 3-dienes via C-F bond activation - Synthesis of 2-fluoro-3-(trifluoromethyl) furans

An efficient synthesis of 2-fluoro-3-(trifluoromethyl)furans was developed. Keystep of the reaction sequence is a [4 + 1] cycloaddition reaction of tin(II)chloride to 4,4-bis(trifluoromethyl)-1-oxabuta-1,3-dienes. At elevated temperatures the tin heterocy

Ein neues Verfahren zur positionsselektiven Einfuehrung von Trifluormethylgruppen in Heteroaromaten: Synthese von 3-Trifluormethylfuranen

Transformation of 4,4-bis(trifluoromethyl)-1-oxabuta-1,3-dienes (2) into 2-fluoro-3-trifluoromethylfurans (4) can be achieved in a two step procedure by treatment with tin(II) chloride and sodium hydride.The fluorine atom at skeleton position 2 is replace