143551-92-2

Upstream product

• 621-59-0 isovanillin 
• 143551-88-6 (E)-3-[4-Methoxy-3-(4-nitro-phenoxy)-phenyl]-acrylic acid 
• 143551-89-7 3-[3-(4-Amino-phenoxy)-4-methoxy-phenyl]-propionic acid 
• 143551-90-0 3-[3-(4-Iodo-phenoxy)-4-methoxy-phenyl]-propionic acid 
• 143551-87-5 4-Methoxy-3-(4-nitro-phenoxy)-benzaldehyde 
• 100-00-5 4-chlorobenzonitrile 
• 176659-13-5 5,5-dimethyl-2-<4-methoxy-3-(4-(2,2-dibromoethenyl)phenoxy)phenyl>-1,3-dioxane 
• 176659-14-6 5,5-dimethyl-2-<4-methoxy-3-<4-(2-(hydroxymethyl)ethynyl)phenoxy>phenyl>-1,3-dioxane 
• 176659-12-4 5,5-dimethyl-2-<4-methoxy-3-(4-formylphenoxy)phenyl>-1,3-dioxane 
• 176659-15-7 4-methoxy-3-<4-(2-(hydroxymethyl)ethynyl)phenoxy>benzaldehyde 
• 176659-11-3 5,5-dimethyl-2-(3-hydroxy-4-methoxyphenyl)-1,3-dioxane 
• 1122-91-4 4-bromo-benzaldehyde 
• 67-56-1 methanol 
• 176659-16-8 (E) ethyl 4-methoxy-3-<4-(2-(hydroxymethyl)ethynyl)phenoxy> cinnamate 

Downstream Products

• 143551-93-3 methyl (Z)-3-<3-<4-(3-hydroxy-1-propenyl)phenoxy>-4-methoxyphenyl> propionate 
• 143551-94-4 (Z)-3-<3-<4-(3-hydroxy-1-propenyl)phenoxy>-4-methoxyphenyl> propionic acid 

Relevant academic research and scientific papers

A facile entry to the caffrane skeletals: Formal synthesis of Combretastatin D-2

Efficient synthesis of Combretastatin D-2, involving a selective reduction of a double bond over a triple bond and a high yielding Ullmann ether formation is described.

Synthesis of Combretastatin D-2+

The synthesis of combretastatin D-2 methyl ether (2) by macrolactonization of hydroxy acid 11 under modified Mitsunobu conditions is described.In accord with the literature, attempts to cyclize 11 via various conventional macrolactonization methods failed.