1436-55-1

Upstream product

• 1209-68-3 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2, 4-dienal 
• 162889-29-4 C₉H₁₇LiO₂ 
• 432-25-7 2,6,6-trimethylcyclohex-1-enecarbaldehyde 
• 157886-41-4 (E)-4-iodo-3-methyl-3-buten-1-al, diethylacetal 
• 20638-88-4 3,7-Dimethyl-1-(2,6,6-trimethyl-cyclohexen-1-yl)-nonatetraen-1,3,5,7-saeure-9-nitril 
• 79-77-6 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one 
• 19834-52-7 3-Methyl-1-(2,6,6-trimethyl-cyclohexen-⁽¹⁾-yl)-pentadien-(1,3)-saeure-⁽⁵⁾-nitril 
• 1856-64-0 C₂₁H₂₇NO₂ 
• 134962-99-5 4-Methyl-6-[(1E,3E)-2-methyl-4-(2,6,6-trimethyl-cyclohex-1-enyl)-buta-1,3-dienyl]-5,6-dihydro-2H-pyran-2-ol 
• 211235-94-8 (E)-5,5-diethoxy-3-methyl-1-(2,6,6-trimethylcyclohex-1-enyl)pent-2-en-1-ol 
• 5560-99-6 (2X,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienal 
• 58274-64-9 (E)-trimethyl((3-methylbuta-1,3-dien-1-yl)oxy)silane 
• 119718-30-8 7-cis,9-cis,11-cis-retinonitrile 
• 68-26-8 (2Z,4Z,6Z,8Z)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraen-1-ol 

Downstream Products

• 857473-23-5 C₂₂H₃₀O₂ 
• 34218-73-0 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nontetraen-1-ol 
• 71423-69-3 4-keto-13-cis-retinal 
• 33532-44-4 4-keto-all-trans-retinal 
• 71423-68-2 4-hydroxy-13-cis-retinal 
• 18344-42-8 4-hydroxy-all-trans-retinal 
• 739-13-9 5,6-epoxy-5,6-dihydroretinal 
• 472-86-6 13-cis-vitamin A aldehyde 
• 116-31-4 all-trans-Retinal 
• 514-85-2 9-cis vitamin A aldehyde 
• 56085-55-3 7-cis,9-cis,13-cis-retinal 
• 56085-53-1 7,9,13-tricis-retinal 
• 67737-37-5 All-cis-Retinal 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS

A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (I); and pharmaceutically acceptable salts thereof.

METHOD FOR PRODUCING SPECIFIC ALPHA,BETA-UNSATURATED ALDEHYDES BY REARRANGEMENT PROCESS

The present invention relates to an improved method for producing specific α,β-unsaturated aldehydes.

METHOD FOR PRODUCING SPECIFIC ALPHA, BETA-UNSATURATED ALDEHYDES

The present invention relates to an improved method for producing specific α, β- unsaturated aldehydes.

Vinyltin acetals in terpenic and nor-terpenic synthesis

Vinyltin acetals obtained by stannylmetallation of homopropargyl acetals with Bu3SnMgMe/CuCN (E configuration) or by titanation of the corresponding alkyltin acetals (Z configuration) have been proved to be efficient storable precursors for the stereoselective synthesis of terpenoids, under mild experimental conditions.Due to the presence of a nucleophilic centre (Csp2-Sn bond) and of a protected electrophilic centre, they are also useful intermediates for an iterative synthesis of retinal and nor-retinoids. - Keywords: vinyltin; acetal; vinyllithium; monoterpenoid; retinal; nor-retinoid

C5-Branched Vinyltin Acetals as Versatile Tools for Terpenic Synthesis

C5-branched vinyltin acetals 1 and 2 obtained by stannylmetallation of homopropargyl acetals with Bu3SnMgMe in the presence of cuprous cyanide have been proved to be efficient storable precursors for the synthesis of terpenoids.

A new prenylation method using the lithium enolate of prenal. Reaction with polyunsaturated aldehydes. A short access to retinal

The enolate of prenal 1 prepared from the corresponding silyl enol ether 2 or enol acetate 3 led to a γ-regiospecific reaction with polyunsaturated aldehydes 4 yielding dihydropyrans 5 leading after hydrolysis to polyenals 7. This process allows the introduction of the isoprenyl skeleton. A synthesis of retinal, from β-ionylidenacetaldehyde is reported.

Transient Phenomena in the Pulse Radiolysis of Retinyl Polyenes. 1. Radical Anions

The spectra and kinetics of formation and decay of radical anions of a number of retinyl polyenes have been studied in methanol and 2-propanol at room temperature, using pulse radiolysis and kinetic spectrophotometry.The bimolecular rate constants for the attachment of solvated electrons, e-MeOH, to the retinyl polyenes are in the diffusion-controlled limit (8.6 x 109-1.6 x 1010 M-1 s-1).The radical anions of retinol and retinol acetate have their spectral maxima at 370-390 nm, and undergo decay very slowly with second-order kinetics.On the other hand, the radical anions of retinal, retinal n-butylamine Schiff base, and retinoic acid/ester have spectral maxima at 430-510 nm, and decay by first-order kinetics in methanol with rate constants in the range 1 x 104-1 x 106 s-1.The decay rates of radical anions of retinal and retinoic acid/ester become considerably longer on going from methanol to less acidic alcohol, 2-propanol, suggesting that protonation by solvent is the major mode of their decay in protic media.In the case of retinal Schiff base, an additional slow process with bimolecular rate constant 9.0 x 107 M-1 s-1 im methanol is observed for the formation of radical anion and is ascribed to the electron-transfer reaction from the methanol radical, .CH2OH.