1436389-37-5

Basic information

• Product Name: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid
• Synonyms: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid
• CAS NO: 1436389-37-5
• Molecular Weight: 423.355
• Mol File: 1436389-37-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid(1436389-37-5)
• EPA Substance Registry System: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine trifluoroacetic acid(1436389-37-5)

Safety Data

• Hazardous Substances Data: 1436389-37-5(Hazardous Substances Data)

Upstream product

• 1436389-35-3 (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid 
• 1436389-46-6 ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate 
• 244059-08-3 tert-butyl N-(3-hydroxy-3-phenylpropyl)-N-methylcarbamate 
• 5053-63-4 3-amino-1-phenylpropan-1-ol 
• 937787-98-9 N-(ethoxycarbonyl)-3-amino-1-phenyl-1-propanol 
• 1394928-30-3 ethyl difluoro(4-hydroxyphenyl)acetate 
• 540-38-5 p-Iodophenol 
• 651316-65-3 tert-butyl methyl{3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}carbamate 
• 76-05-1 trifluoroacetic acid 

Relevant articles and documents

Catalytic decarboxylative fluorination for the synthesis of Tri- and difluoromethyl arenes

Treatment of readily available α,α-difluoro- and α-fluoroarylacetic acids with Selectfluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [18F]labeling is demonstrated using [ 18F]Selectfluor bis(triflate), a reagent affording [ 18F]tri- and [18F]difluoromethylarenes not within reach with [18F]F2.