143774-55-4

Usage

Indole derivative

Heterocyclic organic compound
A compound that is derived from the indole structure, which is a heterocyclic (having a ring with one or more non-carbon atoms) organic compound.

Bromomethyl group

Attached to the indole ring
A functional group consisting of a bromine atom bonded to a methyl group (one carbon atom with three hydrogen atoms), which is attached to the indole ring of the compound.

Phenylsulfonyl group

Attached to the indole ring
A functional group composed of a phenyl ring (a six-membered carbon ring with delocalized electrons) bonded to a sulfonyl group (a sulfur atom double-bonded to two oxygen atoms), which is attached to the indole ring of the compound.

Acetyl group

Position 3 of the indole ring
A functional group consisting of a carbonyl group (a carbon atom double-bonded to an oxygen atom) bonded to a methyl group (one carbon atom with three hydrogen atoms), which is located at the 3rd position of the indole ring.

Potential applications

Organic synthesis and medicinal chemistry
The compound may have possible uses in the fields of organic synthesis (the creation of new organic compounds) and medicinal chemistry (the study of compounds for potential pharmaceutical applications).

Safety precautions

Handle and use with care
As with all potentially hazardous chemicals, it is important to handle and use 1H-Indole, 3-acetyl-2-(bromomethyl)-1-(phenylsulfonyl)with appropriate safety measures to minimize risks to health and the environment.

Upstream product

• 113685-33-9 3-acetyl-2-methyl-1-(phenylsulfonyl)indole 
• 40899-71-6 1-benzenesulfonylindole 
• 22582-52-1 3-acetyl-2-methylindole 
• 95-20-5 2-methyl-1H-indole 
• 85678-41-7 N-benzenesulphonyl-2-methyl-3-thiophenoxyindole 
• 80360-21-0 1-(benzenesulfonyl)-2-methyl-1H-indole 

Downstream Products

• 172877-92-8 1-methyl-4-phenylsulfonyl-2-(p-tolyl)-2,4-dihydropyrrolo<3,4-b>indole 
• 172877-93-9 2-(p-methoxyphenyl)-1-methyl-4-phenylsulfonyl-2,4-dihydropyrrolo<3,4-b>indole 
• 172877-91-7 2-benzyl-1-methyl-4-phenylsulfonyl-2,4-dihydropyrrolo<3,4-b>indole 
• 856111-14-3 1-phenylsulfonyl-2-phenylthiomethyl-3-acetylindole 
• 1445973-83-0 C₃₅H₂₈NO₃PS 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues

A series of calothrixin B (2) analogues bearing substituents at the 'E' ring and their corresponding deoxygenated quinocarbazoles lacking quinone unit were synthesized. The cytotoxicities of calothrixins 1, 2, and 15b-p and quinocarbazole analogues were i

Synthesis of calothrixins and its analogs using FeCl3-mediated domino reaction protocol

A novel one pot synthesis of calothrixin B and its analogs is achieved involving an FeCl3-mediated domino reaction of enamines in dry DMF at reflux. Alternatively, the enamines upon interaction with CuBr2 in DMF at reflux led to the

Synthesis of di-, tri-, and tetra-substituted carbazole analogs involving annulation methodology

Synthesis of substituted carbazole analogs was achieved via Michael addition followed by intramolecular cyclization and subsequent aromatization.

Synthesis of N-protected indolaldehydes using modified Hass procedure

A detailed study on oxidation of N-protected bromomethylindoles into the respective aldehydes was carried out. Using a modified Hass procedure, synthesis of aryl-/hetero-aryl aldehydes in particular indolaldehydes is achieved in reasonable yields.

An efficient preparation of 1-phenylsulfonylindolyl methyl sulfoxides using KF/m-CPBA

A variety of 1-phenylsulfonylindolylmethyl sulfides are selectively oxidized to the corresponding sulfoxides using a hitherto unexplored KF/m-CPBA system. A major advantage is the absence of over-oxidation.

Synthesis and cycloaddition of 2,4-dihydropyrroloindoles

Friedel-Crafts acylation of 2-methyl-1-phenylsulfonylindole 6 gave the 3-acyl derivatives 7 which upon side chain bromination with N-bromosuccinimide (NBS) followed by treatment with primary amines afforded the title compounds 9.Diels-Alder reaction of 9 with dimethyl acetylenedicarboxylate (DMAD) gave the polysubstituted carbazoles 12.