1438244-06-4

Basic information

• Product Name: N-tert-butyl-N'-[4-(trifluoromethyl)phenylmethylidene]sulfamide
• Synonyms: N-tert-butyl-N'-[4-(trifluoromethyl)phenylmethylidene]sulfamide
• CAS NO: 1438244-06-4
• Molecular Weight: 308.325
• Mol File: 1438244-06-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-tert-butyl-N'-[4-(trifluoromethyl)phenylmethylidene]sulfamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyl-N'-[4-(trifluoromethyl)phenylmethylidene]sulfamide(1438244-06-4)
• EPA Substance Registry System: N-tert-butyl-N'-[4-(trifluoromethyl)phenylmethylidene]sulfamide(1438244-06-4)

Safety Data

• Hazardous Substances Data: 1438244-06-4(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 49689-97-6 N-tert-butylsulfamide 

Downstream Products

• 1351866-47-1 (R)-(+)-N-[(4-trifluoromethylphenyl)(phenyl)methyl]acetamide 
• 154233-38-2 C-phenyl-C-(4-trifluoromethyl-phenyl)-methylamine 
• 1438244-18-8 (R)-N-tert-butyl-N'-((4-trifluoromethylphenyl)(phenyl)methyl)sulfamide 
• 1438244-23-5 (S)-N-tert-butyl-N'-((4-trifluoromethylphenyl)(phenyl)methyl)sulfamide 

Relevant articles and documents

N-(Alkylsulfamoyl)aldimines: Easily deprotected precursors for diarylmethylamine synthesis

The sequential reaction of chlorosulfonyl isocyanate with t-BuOH, t-BuNH2 and TFA allows formation of H2NSO 2NHBut. Condensation of the latter with Ar1CHO in the presence of Ti(OEt)4 provides the activated imines Ar 1CHNSO2NHBut (59-89%). Commercially available boronic acids add to these imines with good stereoselectivity (76-98% ee) using readily available diene ligands. Simple deprotection with 5% w/w water in pyridine affords free Ar1CHNH2Ar2.