1438244-18-8Relevant articles and documents
N-(Alkylsulfamoyl)aldimines: Easily deprotected precursors for diarylmethylamine synthesis
Crampton, Rosemary H.,Fox, Martin,Woodward, Simon
, p. 599 - 605 (2013/06/27)
The sequential reaction of chlorosulfonyl isocyanate with t-BuOH, t-BuNH2 and TFA allows formation of H2NSO 2NHBut. Condensation of the latter with Ar1CHO in the presence of Ti(OEt)4 provides the activated imines Ar 1CHNSO2NHBut (59-89%). Commercially available boronic acids add to these imines with good stereoselectivity (76-98% ee) using readily available diene ligands. Simple deprotection with 5% w/w water in pyridine affords free Ar1CHNH2Ar2.