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154233-38-2

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154233-38-2 Usage

General Description

1-Phenyl-1-[4-(trifluoromethyl)phenyl]methanamine, also known as 4-Trifluoromethyl-phenyl-isobutyrylamine, is an organic compound with the molecular formula C16H15F3N. It is a substituted phenethylamine that is commonly used in pharmaceutical research as a precursor in the synthesis of various medicinal chemicals and drugs. 1-phenyl-1-[4-(trifluoromethyl)phenyl]methanamine is known for its potential as a central nervous system stimulant and has been the subject of research for its potential applications in the treatment of various mental and neurological disorders. Additionally, it has gained attention for its potential use as an intermediary in the production of designer drugs and psychoactive substances.

Check Digit Verification of cas no

The CAS Registry Mumber 154233-38-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,2,3 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 154233-38:
(8*1)+(7*5)+(6*4)+(5*2)+(4*3)+(3*3)+(2*3)+(1*8)=112
112 % 10 = 2
So 154233-38-2 is a valid CAS Registry Number.

154233-38-2Relevant articles and documents

Hydrogen bond directed aerobic oxidation of amines via photoredox catalysis

Wang, Hongyu,Man, Yunquan,Wang, Kaiye,Wan, Xiuyan,Tong, Lili,Li, Na,Tang, Bo

, p. 10989 - 10992 (2018/10/08)

An application of H-bonding interactions for directing the α-C-H oxidation of amines to amides and amino-ketones catalyzed by an organic photocatalyst is reported. The high efficiency of this method is demonstrated by the aerobic oxidation of pyrrolidines, diarylamines and benzylamines bearing urea groups with high yields and a wide substrate scope.

THERAPEUTIC METHODS

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Page/Page column 45; 46, (2013/06/27)

The present invention relates to methods of treatment of diseases mediated by ROR?.

α-Methylation at benzylic fragment of N-aryl-N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

Gomtsyan, Arthur,Bayburt, Erol K.,Keddy, Ryan,Turner, Sean C.,Jinkerson, Tammie K.,Didomenico, Stanley,Perner, Richard J.,Koenig, John R.,Drizin, Irene,McDonald, Heath A.,Surowy, Carol S.,Honore, Prisca,Mikusa, Joe,Marsh, Kennan C.,Wetter, Jill M.,Faltynek, Connie R.,Lee, Chih-Hung

, p. 3894 - 3899 (2008/02/09)

SAR studies for N-aryl-N′-benzyl urea class of TRPV1 antagonists have been extended to cover α-benzyl alkylation. Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties. Further structural manipulations that included replacement of isoquinoline core with indazole and isolation of single enantiomer led to TRPV1 antagonists like (R)-16a with superior pharmacokinetic properties and greater potency in animal model of inflammatory pain.

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