1351866-47-1

Basic information

• Product Name: (R)-(+)-N-[(4-trifluoromethylphenyl)(phenyl)methyl]acetamide
• Synonyms: (R)-(+)-N-[(4-trifluoromethylphenyl)(phenyl)methyl]acetamide
• CAS NO: 1351866-47-1
• Molecular Weight: 293.288
• Mol File: 1351866-47-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-(+)-N-[(4-trifluoromethylphenyl)(phenyl)methyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-N-[(4-trifluoromethylphenyl)(phenyl)methyl]acetamide(1351866-47-1)
• EPA Substance Registry System: (R)-(+)-N-[(4-trifluoromethylphenyl)(phenyl)methyl]acetamide(1351866-47-1)

Safety Data

• Hazardous Substances Data: 1351866-47-1(Hazardous Substances Data)

Upstream product

• 1438244-18-8 (R)-N-tert-butyl-N'-((4-trifluoromethylphenyl)(phenyl)methyl)sulfamide 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 1438244-04-2 N-tert-butyl-N'-[phenylmethylidene]sulfamide 
• 1438244-02-0 N-methyl-N'-[phenylmethylidene]sulfamide 
• 100-52-7 benzaldehyde 
• 1438244-06-4 N-tert-butyl-N'-[4-(trifluoromethyl)phenylmethylidene]sulfamide 
• 2786-01-8 (4-trifluoromethylphenyl)lithium 
• 108-24-7 acetic anhydride 
• 154233-38-2 C-phenyl-C-(4-trifluoromethyl-phenyl)-methylamine 
• 98-80-6 phenylboronic acid 
• 641620-70-4 C₉H₁₂BNO₃ 

Relevant articles and documents

N-(Alkylsulfamoyl)aldimines: Easily deprotected precursors for diarylmethylamine synthesis

The sequential reaction of chlorosulfonyl isocyanate with t-BuOH, t-BuNH2 and TFA allows formation of H2NSO 2NHBut. Condensation of the latter with Ar1CHO in the presence of Ti(OEt)4 provides the activated imines Ar 1CHNSO2NHBut (59-89%). Commercially available boronic acids add to these imines with good stereoselectivity (76-98% ee) using readily available diene ligands. Simple deprotection with 5% w/w water in pyridine affords free Ar1CHNH2Ar2.