14383-56-3

Upstream product

• 51-67-2 tyrosamine 
• 108-24-7 acetic anhydride 
• 64-04-0 phenethylamine 
• 1323952-86-8 2-phenylethan-1-aminium trifluoromethanesulfonate 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 1202-66-0 N-acetyltyramine 

Downstream Products

• 1202-66-0 N-acetyltyramine 

Relevant academic research and scientific papers

Alkaloids from Crinum moorei

Thirteen alkaloids were isolated from Crinum moorei two of which are new. These are 3-[4′-(8′-aminoethyl)phenoxy] bulbispermine and mooreine. The structures of the new alkaloids were determined by spectroscopic methods.

Larvicidal activity of single and macrocyclic tyrosine derivatives against three important vector mosquitoes

The larvicidal activity of several phenylethylamines derived from l-tyrosine against larvae of the mosquito species Anopheles albimanus, Aedes aegypti, and Culex quinquefasciatus was studied. The results showed that the phenylethylamine nucleus present in

Easy Synthesis of a Self-Assembled Imine-Based Iron(II) Complex Endowed with Crown-Ether Receptors

Herein we report that an imine-based iron complex decorated with crown-ether moieties self-assembles in CH3CN solution from three building blocks (namely Fe(CH3CN)2(OTf)2, 2-picolylamine and aldehyde 6a) added in the proper molar ratio (1:2:2, respectively). Aldehyde 6a, endowed with a benzocrown-ether receptor, can be prepared in two steps from commercial materials with high yields (79 percent) and no need of chromatographic separations. The self-assembled complex is highly stable in CH3CN solution. The complex has been tested as catalyst for the oxidation of aromatic compounds endowed with primary ammonium anchoring group with H2O2. An unexpected yet moderate selectivity for remote meta over ortho hydroxylation was obtained, which is mainly due to the steric hindrance of the catalyst.

Silica-supported boric acid catalyzed synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, esters and amides

Silica-supported boric acid (H3BO3-SiO2) has been established as a green, efficient and recyclable catalyst for the synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, and acetylation of alcohols, phenols, amines and thiols under solvent free conditions. The main features of the present method include clean reaction, mild conditions, low loading of environment friendly catalyst and easy workup procedure. The catalyst can be recycled at least five times without any significant loss in activity.

The use of immobilized crown ethers as in-situ N-protecting groups in organic synthesis and their application under continuous flow

In addition to their high affinity for inorganic cations, crown ethers have been shown to efficiently sequester ammonium ions, forming a stable adduct via hydrogen bonding. Using this principle, several authors have reported the use of crown ethers as protecting groups for amines however to date, their widespread use has been somewhat precluded by the difficulties associated with removal of the crown ether from the resulting reaction mixture. In order to address this problem, we report the preparation of an immobilized 18-crown-6 ether derivative and its incorporation into a flow reactor, demonstrating the ability to use and recycle the reagent for the chemoselective O-acylation and alkylation of bifunctional compounds such as 4-(2-aminoethyl)phenol and 4-nitrophenol.

Pyrimidine derivatives and processes for the preparation thereof

The present invention relates to novel pyrimidine derivatives of formula (I) or pharmaceutically acceptable salts thereof which possess an excellent anti-secretory activity, pharmaceutical compositions containing the same as an active ingredient, their novel intermediates, and processes for the preparation thereof wherein: when A is piperidin-1-yl or —NH—B, wherein B is C3-C4alkyl, C3-C4alkenyl, C3-C7cycloalkyl, C1-C3alkoxyethyl, phenylethl which may be substituted or unsubstituted, 3-trifluoromethylphenylmethyl, 1-naphthylmethyl, 4-methylthiazol-2-yl or 4-phenylthiazol-2-yl, R1is hydrogen or methyl; and R2, R3, R4and R5are hydrogen; or when A is a group of formula (II); when R1is hydroxymethyl or C1-C3alkoxymethyl, R2, R3, R4, R5and R6are hydrogen; and R7is hydrogen or halogen; or when R1is hydrogen or methyl, R7is hydrogen or halogen; and one or two of R2, R3, R4, R5and R6is hydroxy, methoxy, or a group of formula (III) wherein Z is C1-C4alkyl, substituted or unsubstituted C1-C4alkenyl, cyloalkyl, benzyloxyalkyl, alkoxycarbonylalkyl, morpholinomethyl, piperidinomethyl, 4-substituted-piperazinomethyl, substituted or unsubstituted phenyl, naphthyl, substituted or unsubstituted benzyl, thiophen-2-yl-methyl, 1-substituted-pyrrolidin-2-yl or —CHR8NHR9, wherein R8is hydrogen, methyl, isopropyl, benzyl, benzyloxymethyl, methylthioethyl, benzyloxycarbonylmethyl, carbamolymethyl, carbamoylethyl, or 1-benzylimidazol-4-ylmethyl and R9is hydrogen or t-butoxycarbonyl; and the others are hydrogen or methyl.

Water-Soluble Acylating Agents: Preparation of 2-Acylthio-1-alkylpyridinium Salts and Acylation of Phenols, Acids, and/or Amines with These Salts in an Aqueous Phase

Reaction of phenols, amines, and acids with 2-benzoylthio-1-methylpyridinium chloride prepared in situ from benzoyl chloride and 1-methyl-2(1H)-pyridinethione, afforded the corresponding benzoyl derivatives in good yields.In the reaction of p-nitrophenol, even catalytic amount of 1-methyl-2(1H)-pyridinethione proved to be effective.Similar reactions of p-nitrophenol with isobutyryl chloride and acetyl chloride in the presence of 1-methyl-2(1H)-pyridinethione afforded p-nitrophenyl isobutyrate and p-nitrophenyl acetate in 63 and 44percent yields, respectively. 2-Benzoylthio-, 2-acetylthio-, and 2-isobutyrylthio-1-ethylpyridinium tetrafluorobora tes were prepared by treatment of the corresponding 2-acylthiopyridines with triethyloxonium tetrafluoroborate.These pyridinium salts also acted as acylating agents in an aqueous phase. some competitive reactions of 2-aminoethanol and phenols with 2-benzoylthio-1-methylpyridinium chloride were also investigated.