143874-16-2Relevant academic research and scientific papers
Ester and amide prodrugs of ibuprofen and naproxen: Synthesis, anti- inflammatory activity, and gastrointestinal toxicity
Shanbhag,Crider,Gokhale,Harpalani,Dick
, p. 149 - 154 (1992)
Ester and amide prodrugs of ibuprofen (1) and naproxen (16) were synthesized and evaluated for anti-inflammatory activity and gastrointestinal toxicity. The chemical structure of the prodrugs was varied in terms of lipophilicity and reactivity toward hydr
