Ester and amide prodrugs of ibuprofen and naproxen: Synthesis, anti- inflammatory activity, and gastrointestinal toxicity

DOI: 10.1002/jps.2600810210

Source and publish data:

Journal of Pharmaceutical Sciences p. 149 - 154 (1992)

Update date:2022-08-03

Topics: Synthesis Amide Ester Anti-Inflammatory Activity Prodrugs Gastrointestinal toxicity

Authors:

Shanbhag

Crider Crider

Gokhale Gokhale

Harpalani

Dick Dick

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Article abstract of DOI:10.1002/jps.2600810210

Ester and amide prodrugs of ibuprofen (1) and naproxen (16) were synthesized and evaluated for anti-inflammatory activity and gastrointestinal toxicity. The chemical structure of the prodrugs was varied in terms of lipophilicity and reactivity toward hydr

Full text of DOI:10.1002/jps.2600810210

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Product name:2-(4-Isobutyl-phenyl)-propionic acid 2-(benzyl-methyl-amino)-ethyl ester

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