Journal of Pharmaceutical Sciences p. 149 - 154 (1992)
Update date:2022-08-03
Topics: Synthesis Amide Ester Anti-Inflammatory Activity Prodrugs Gastrointestinal toxicity
Shanbhag
Crider
Gokhale
Harpalani
Dick
Ester and amide prodrugs of ibuprofen (1) and naproxen (16) were synthesized and evaluated for anti-inflammatory activity and gastrointestinal toxicity. The chemical structure of the prodrugs was varied in terms of lipophilicity and reactivity toward hydr
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(1992)Doi:10.4067/S0717-97072013000200008
(2013)Doi:10.1016/j.jsbmb.2010.02.016
(2010)Doi:10.1021/jo400721e
(2013)Doi:10.1016/S0040-4039(99)01606-8
(1999)
