143925-52-4

Basic information

• Product Name: N-(2-FLUOROPHENYL)-4-METHOXYBENZAMIDE
• Synonyms: N-(2-FLUOROPHENYL)-4-METHOXYBENZAMIDE
• CAS NO: 143925-52-4
• Molecular Formula: C₁₄H₁₂FNO₂
• Molecular Weight: 245.25
• Mol File: 143925-52-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-FLUOROPHENYL)-4-METHOXYBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-FLUOROPHENYL)-4-METHOXYBENZAMIDE(143925-52-4)
• EPA Substance Registry System: N-(2-FLUOROPHENYL)-4-METHOXYBENZAMIDE(143925-52-4)

Safety Data

• Hazardous Substances Data: 143925-52-4(Hazardous Substances Data)

Upstream product

• 3296-04-6 1-azido-2-fluorobenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 348-54-9 2-Fluoroaniline 
• 100-07-2 4-methoxy-benzoyl chloride 
• 201230-82-2 carbon monoxide 
• 3058-39-7 4-iodobenzonitrile 
• 369-36-8 6-fluoro-3-nitroaniline 
• 696-62-8 para-iodoanisole 
• 535-52-4 2-fluoro-5-(trifluoromethyl)aniline 
• 771-60-8 2,3,4,5,6-pentafluoroaniline 

Downstream Products

• 913382-73-7 C₁₄H₁₂FNOS 
• 913382-74-8 4-fluoro-2-(4-methoxyphenyl)-1,3-benzothiazole 

Relevant articles and documents

Selective radical amination of aldehydic C(sp2)-H bonds with fluoroaryl azides via Co(ii)-based metalloradical catalysis: Synthesis of N-fluoroaryl amides from aldehydes under neutral and nonoxidative conditions

The Co(ii) complex of the D2h-symmetric amidoporphyrin 3,5-DitBu-IbuPhyrin, [Co(P1)], has proven to be an effective metalloradical catalyst for intermolecular amination of C(sp2)-H bonds of aldehydes with fluoroaryl azides. The [Co(P1)]-catalyzed process can employ aldehydes as the limiting reagents and operate under neutral and nonoxidative conditions, generating nitrogen gas as the only byproduct. The metalloradical aldehydic C-H amination is suitable for different combinations of aldehydes and fluoroaryl azides, producing the corresponding N-fluoroaryl amides in good to excellent yields. A series of mechanistic studies support a stepwise radical mechanism for the Co(ii)-catalyzed intermolecular C-H amination. This journal is the Partner Organisations 2014.

Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols')

The synthesis and in vitro antitumour evaluation of a new series of fluorinated benzothiazole-substituted 4-hydroxycyclohexa-2,5-dienones ('quinols') is described. The new compounds were found to be of comparable activity compared to the non-fluorinated precursor PMX 464, in terms of antiproliferative activity in sensitive human cancer cell lines (nanomolar GI50 values) and inhibitory activity against the thioredoxin signalling system.