144-54-7

Basic information

• Product Name: methyldithiocarbamic acid
• Synonyms: methyldithiocarbamic acid;methyldithiocarbamate;N-METHYLDITHIOCARBAMICACID
• CAS NO: 144-54-7
• Molecular Formula: C₂H₅NS₂
• Molecular Weight: 107.1978
• EINECS: 205-632-2
• Mol File: 144-54-7.mol

Chemical Properties

• Melting Point: 163-166 °C
• Boiling Point: 120.3 °C at 760 mmHg
• Flash Point: 26.6 °C
• Appearance: /
• Density: 1.199 g/cm³
• Vapor Pressure: 15.3mmHg at 25°C
• Refractive Index: 1.588
• PKA: 4.63±0.60(Predicted)
• CAS DataBase Reference: methyldithiocarbamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: methyldithiocarbamic acid(144-54-7)
• EPA Substance Registry System: methyldithiocarbamic acid(144-54-7)

Safety Data

• Hazardous Substances Data: 144-54-7(Hazardous Substances Data)

Usage

Uses

Used in Agricultural and Industrial Applications:
Methyldithiocarbamic acid is used as a pesticide and microbiocide for controlling a wide range of pests and microorganisms, ensuring the protection and preservation of crops and industrial materials.
Used in Water Treatment:
Methyldithiocarbamic acid is used as a chelating agent in water treatment processes, helping to remove impurities and improve water quality.
Used in Rubber Vulcanization:
The complexes of methyldithiocarbamic acid are used as additives in the rubber vulcanization process, enhancing the properties and performance of rubber products.
Used in Chemical Synthesis:
Methyldithiocarbamic acid is utilized in the synthesis of other chemicals, such as dithiocarbamate-based fungicides, contributing to the development of new and effective products for various industries.
However, it is crucial to handle methyldithiocarbamic acid with caution due to its toxic and corrosive nature, which can cause skin and eye irritation. Prolonged exposure may also have harmful effects on human health and the environment.

InChI:InChI=1/C2H5NS2/c1-3-2(4)5/h1H3,(H2,3,4,5)

Upstream product

• 556-61-6 methyl thioisocyanate 
• 21844-99-5 S-(N-Methylthiocarbamoyl)-L-cysteine 
• 75-15-0 carbon disulfide 
• 74-89-5 methylamine 

Downstream Products

• 75-15-0 carbon disulfide 
• 74-89-5 methylamine 
• 6610-29-3 4-methylthiosemicarbazide 
• 137-42-8 sodium N-methyldithiocarbamate 
• 13037-11-1 S-methyl N-methyl dithiocarbamate 

Relevant articles and documents

Method for synthesizing metham in one step

The invention discloses a method for synthesizing a soil fumigant metham in one step. The method comprises the following steps: stirring and mixing water, a monomethylamine aqueous solution and a sodium hydroxide aqueous solution, dropwise adding carbon disulfide, continuously stirring and reacting to obtain a finished product of metham with the appearance of yellow to red brown, wherein the finished product is used for treating soil fumigation and disinfection and killing root-knot nematodes, harmful bacteria and soil insects and removing weeds. The whole synthesis method has the advantages of high production efficiency, high product content, high operation safety, good storage stability and environmental friendliness.

N - alkyl dithiocarbamate and preparation and application thereof (by machine translation)

The invention provides preparation and application of N - alkyl dithiocarbamate and a water agent thereof, N - alkyl dithiocarbamate has the structural formula shown in the specification. Method 1: (a) dropwise addition of carbon disulfide to an aqueous amine solution; (b) adding aqueous ammonia to N - alkyl dithiocarbamic acid aqueous solution obtained in step (a); (b) mixing water, ammonia water and monoalkylamine, adding carbon disulfide dropwise and ending the reaction to obtain N - alkyl dithiocarbamic acid ammonium water aqua water aqua water aqua: (b) an aqueous solution of N-alkyldithiocarbamic acid 2. The product provided by the invention is applied to the soil fumigation and disinfection treatment, has obvious weeding and killing performance of the root-knot nematode, and can be used for effectively improving the soil hardening phenomenon. (by machine translation)

Dazomet preparation process

The invention discloses a dazomet preparation process. The process comprises the following steps: of the first step reaction: enabling methylamine to react with carbon disulfide, adding an appropriate amount of extracting agent, separating to obtain an intermediate N-methylaminodithioformate; the second step reaction: enabling the intermediate N-methylaminodithioformate to react with formaldehyde in a reaction system added with an appropriate amount of sulfate and surfactant to obtain the dazomet. By use of the scheme disclosed by the invention, the extracting agent is added after the first step reaction is finished; the product carbon disulfide is further removed, thereby avoiding the influence on the product crystal structure, packing density and production security by residual carbon disulfide.

Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates

A series of 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl) propyl dithiocarbamates as new analogs of fluconazole were synthesized and their antifungal activities were evaluated. Among these compounds, 2a-f and 3a-q exhibited higher activities than fluconazole against nearly all fungi tested except Aspergillus fumigatus. Noticeably, the in vitro biological activities of 2b, 3a, 3c, 3h-k, and 3o-q against Candida species were much better than those of fluconazole and ketoconazole. Also, 2a-d, 3a-d, 3e-f, 3h-k, 3p and 3q showed higher activities against A. fumi than fluconazole. Computational docking experiments indicated that the inhibition of CYP51 involved a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft.

Synthesis of new hyodeoxycholic acid thiosemicarbazone derivatives under solvent-free conditions using microwave

An efficient and simple method for synthesis of new hyodeoxycholic acid thiosemicarbazone derivatives under solvent-free conditions using microwave has been developed. Its main advantages are short reaction times, good conversions and the environmentally friendly nature of the process. The preliminary results indicate that some of these compounds possess inhibitory effects against E. coli.

Solvent-free synthesis of indole-based thiosemicarbazones under microwave irradiation

A rapid, effi cient and environmentally friendly methodology has been developed for the synthesis of indole-3-carboxaldehyde thiosemicarbazones by using aluminum oxide as the solid support under microwave assisted solvent-free conditions. Compared with the conventional heating method, this method gave the target products in good yield.

Inactivation of Amino Acid Racemase by S-(N-Methylthiocarbamoyl)-D,L-cysteine

S-(N-Methylthiocarbamoyl)-D- and L-cysteine (MTCC) are new irreversible inhibitors of the amino acid racemase from Pseudomonas putida.Interactions between D- or L-MTCC and purified amino acid racemase were investigated.The racemase catalyzes not only racemization reactions of D- and L-MTCC but also their α,β-elimination reactions with concomitant inactivation.This inactivation exhibits the characteristics of suicide inhibition, i.e., pseudo-first order kinetics, irreversibility, stoichiometric labeling of active enzyme by the C3 chain derived from MTCC, and protection by substrate.