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1440428-01-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1440428-01-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,0,4,2 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1440428-01:
122 % 10 = 2
So 1440428-01-2 is a valid CAS Registry Number.

1440428-01-2Downstream Products

1440428-01-2Relevant articles and documents

A thiazole and pyridine ester compound and its preparation method


, (2018/01/19)

The invention relates to a thienopyridine ester compound and a preparation method thereof. The thienopyridine ester compound is 6-chloro-2-thiazole [4, 5-b] picolinic acid methyl ester. The preparation method comprises the following steps: (1) obtaining benzoyl protected thiourea-containing derivative compound 2 by using a compound 13,5-dichloro-2-aminopyridine as a starting material in the presence of benzoyl chloride and ammonium thiocyanate; (2) hydrolyzing the compound 2 so as to obtain a thiourea derivative compound 3; (3) carrying out ring-closing reaction on the compound 3 under the action of sodium hydride so as to generate a compound 4; (4) deaminizing the compound 4 by using isoamyl nitrite so as to obtain a target compound 5; and (5) carrying out catalytic carbonyl insertion on the compound 5 by using carbon monoxide so as to obtain a target compound 6. The preparation method is a 6-chloro-2-thiazole [4, 5-b] picolinic acid methyl ester preparation method which has the advantages that raw materials are low in cost, and the synthetic method is simple. The product prepared by the method has a wide application prospect in the preparation of anti-inflammatory medicines.

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