1440428-01-2

Basic information

• Product Name: Methyl 6-chlorothiazolo[4,5-b]pyridine-2-carboxylate
• Synonyms: Methyl 6-chlorothiazolo[4,5-b]pyridine-2-carboxylate
• CAS NO: 1440428-01-2
• Molecular Formula: C8H5ClN2O2S
• Molecular Weight: 228.6555
• Mol File: 1440428-01-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 332.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.531±0.06 g/cm3(Predicted)
• PKA: -3.49±0.50(Predicted)
• CAS DataBase Reference: Methyl 6-chlorothiazolo[4,5-b]pyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-chlorothiazolo[4,5-b]pyridine-2-carboxylate(1440428-01-2)
• EPA Substance Registry System: Methyl 6-chlorothiazolo[4,5-b]pyridine-2-carboxylate(1440428-01-2)

Safety Data

• Hazardous Substances Data: 1440428-01-2(Hazardous Substances Data)

Upstream product

• 31545-32-1 (3,5-dichloro-pyridin-2-yl)-thiourea 
• 31430-20-3 N-((3,5-dichloropyridin-2-yl)carbamothioyl)benzamide 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 

Relevant articles and documents

A thiazole and pyridine ester compound and its preparation method

The invention relates to a thienopyridine ester compound and a preparation method thereof. The thienopyridine ester compound is 6-chloro-2-thiazole [4, 5-b] picolinic acid methyl ester. The preparation method comprises the following steps: (1) obtaining benzoyl protected thiourea-containing derivative compound 2 by using a compound 13,5-dichloro-2-aminopyridine as a starting material in the presence of benzoyl chloride and ammonium thiocyanate; (2) hydrolyzing the compound 2 so as to obtain a thiourea derivative compound 3; (3) carrying out ring-closing reaction on the compound 3 under the action of sodium hydride so as to generate a compound 4; (4) deaminizing the compound 4 by using isoamyl nitrite so as to obtain a target compound 5; and (5) carrying out catalytic carbonyl insertion on the compound 5 by using carbon monoxide so as to obtain a target compound 6. The preparation method is a 6-chloro-2-thiazole [4, 5-b] picolinic acid methyl ester preparation method which has the advantages that raw materials are low in cost, and the synthetic method is simple. The product prepared by the method has a wide application prospect in the preparation of anti-inflammatory medicines.