31430-20-3

Upstream product

• 4214-74-8 3,5-dichloropyridin-2-amine 
• 98-88-4 benzoyl chloride 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 31545-32-1 (3,5-dichloro-pyridin-2-yl)-thiourea 
• 1440428-01-2 methyl 6-chloro-2-thiazolo[4,5-b]pyridinecarboxylate 
• 100856-65-3 N-(6-chlorothiazolo[4,5-b]pyridin-2-yl)benzamide 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR TREATING CANCER

Substituted hydrazone compounds, methods of making such compounds and metal complexes thereof, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds and metal complexes to treat, prevent or ameliorate cancer are provided.

A thiazole and pyridine ester compound and its preparation method

The invention relates to a thienopyridine ester compound and a preparation method thereof. The thienopyridine ester compound is 6-chloro-2-thiazole [4, 5-b] picolinic acid methyl ester. The preparation method comprises the following steps: (1) obtaining benzoyl protected thiourea-containing derivative compound 2 by using a compound 13,5-dichloro-2-aminopyridine as a starting material in the presence of benzoyl chloride and ammonium thiocyanate; (2) hydrolyzing the compound 2 so as to obtain a thiourea derivative compound 3; (3) carrying out ring-closing reaction on the compound 3 under the action of sodium hydride so as to generate a compound 4; (4) deaminizing the compound 4 by using isoamyl nitrite so as to obtain a target compound 5; and (5) carrying out catalytic carbonyl insertion on the compound 5 by using carbon monoxide so as to obtain a target compound 6. The preparation method is a 6-chloro-2-thiazole [4, 5-b] picolinic acid methyl ester preparation method which has the advantages that raw materials are low in cost, and the synthetic method is simple. The product prepared by the method has a wide application prospect in the preparation of anti-inflammatory medicines.

Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.