1440522-77-9Relevant academic research and scientific papers
Multifactorial control of iteration events in a modular polyketide assembly line
Busch, Benjamin,Ueberschaar, Nico,Behnken, Swantje,Sugimoto, Yuki,Werneburg, Martina,Traitcheva, Nelly,He, Jing,Hertweck, Christian
, p. 5285 - 5289 (2013/06/26)
Freedom and control: First insights into the rare programmed iteration of an individual polyketide synthase (PKS) module were obtained from the analysis and mutation of aureothin (1) synthase. The first ketosynthase (KS) domain primes the PKS, allowing intermediate retrotransfer. Addition of a designated loading module results in a complete loss of iteration. The downstream KS functions as a gatekeeper for correct chain length. Copyright
