59488-85-6Relevant academic research and scientific papers
Multifactorial control of iteration events in a modular polyketide assembly line
Busch, Benjamin,Ueberschaar, Nico,Behnken, Swantje,Sugimoto, Yuki,Werneburg, Martina,Traitcheva, Nelly,He, Jing,Hertweck, Christian
, p. 5285 - 5289 (2013/06/26)
Freedom and control: First insights into the rare programmed iteration of an individual polyketide synthase (PKS) module were obtained from the analysis and mutation of aureothin (1) synthase. The first ketosynthase (KS) domain primes the PKS, allowing intermediate retrotransfer. Addition of a designated loading module results in a complete loss of iteration. The downstream KS functions as a gatekeeper for correct chain length. Copyright
Convergent asymmetric synthesis of (+)-aureothin employing an oxygenase-mediated resolution step
Henrot, Matthias,Richter, Martin E.A.,Maddaluno, Jacques,Hertweck, Christian,De Paolis, Micha?l
, p. 9587 - 9591 (2012/10/30)
Need an enzymatic push? The desymmetrization of α,α'-dimethoxy- γ-pyrone allows the convergent and rapid preparation of the complete carbon skeleton of (+)-aureothin (see scheme). The final step in the synthesis of the target molecule is the regiodivergen
Biomimetic studies on polyenes.
Moses, John E,Baldwin, Jack E,Brueckner, Sebastien,Eade, Serena J,Adlington, Robert M
, p. 3670 - 3684 (2007/10/03)
The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions. The reaction pathways provide insight into the biosynthesis of these complex natural products.
Studies on the biomimetic synthesis of SNF4435 C and D
Moses, John E.,Baldwin, Jack E.,Marquez, Rodolfo,Adlington, Robert M.,Cowley, Andrew R.
, p. 3731 - 3734 (2007/10/03)
(equation Presented) The biomimetic synthesis of the bicyclic core of the novel immunosuppresants SNF4435C and SNF4435D is reported. The core framework was efficiently generated from the all-trans tetraene precursor in one step and in good yield.
