476418-12-9

Basic information

• Product Name: 2,4,6-Heptatrienoic acid, 2,4,6-trimethyl-7-(4-nitrophenyl)-, ethyl ester, (2E,4E,6E)-
• CAS NO: 476418-12-9
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.369
• Mol File: 476418-12-9.mol

Chemical Properties

• CAS DataBase Reference: 2,4,6-Heptatrienoic acid, 2,4,6-trimethyl-7-(4-nitrophenyl)-, ethyl ester, (2E,4E,6E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-Heptatrienoic acid, 2,4,6-trimethyl-7-(4-nitrophenyl)-, ethyl ester, (2E,4E,6E)-(476418-12-9)
• EPA Substance Registry System: 2,4,6-Heptatrienoic acid, 2,4,6-trimethyl-7-(4-nitrophenyl)-, ethyl ester, (2E,4E,6E)-(476418-12-9)

Safety Data

• Hazardous Substances Data: 476418-12-9(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 53618-29-4 (E)-ethyl 2-methyl-3-(4-nitrophenyl)acrylate 
• 59488-85-6 (2E,4E)-2,4-dimethyl-5-(4-nitrophenyl)penta-2,4-dienol 
• 22388-91-6 ethyl (2E,4E)-2,4-dimethyl-5-(4-nitrophenyl)penta-2,4-dienoate 
• 37542-81-7 (2E)-2-methyl-3-(4-nitrophenyl)prop-2-en-1-ol 
• 58550-34-8 (E)-2-methyl-3-(4-nitrophenyl)acrylaldehyde 
• 59488-84-5 (2E,4E)-2,4-dimethyl-5-(p-nitrophenyl)pentan-2,4-dienal 
• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 

Downstream Products

• 1440522-77-9 (2E,4E,6E,8E)-2,4,6,8-tetramethyl-9-(4-nitrophenyl)nona-2,4,6,8-tetraenoic acid 
• 1440522-76-8 (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trienoic acid 
• 627079-62-3 ethyl (2E,4E,6E,8E,10E)-4,6,8,10-tetramethyl-11-(4-nitrophenyl)undeca-2,4,6,8,10-pentaenoate 
• 627079-60-1 ethyl (2E,4E,6E,8E)-2,4,6,8-tetramethyl-9-(4-nitrophenyl)nona-2,4,6,8-tetraenoate 
• 648414-22-6 (2E,4E,6E,8E)-2,4,6,8-Tetramethyl-9-(4-nitro-phenyl)-nona-2,4,6,8-tetraen-1-ol 
• 627079-61-2 (2E,4E,6E,8E)-2,4,6,8-tetramethyl-9-(4-nitrophenyl)nona-2,4,6,8-tetraenal 
• 476418-14-1 (2E,4E,6E,8E)-4,6,8-trimethyl-9-(4-nitro-phenyl)-nona-2,4,6,8-tetraenoic acid ethyl ester 
• 476418-18-5 (2E,4E,6E,8E)-4,6,8-trimethyl-9-(4-nitro-phenyl)-nona-2,4,6,8-tetraenoic acid methyl ester 
• 78847-04-8 (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-2,4,6-trienal 
• 648414-16-8 (2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)hepta-2,4,6-trien-1-ol 

Relevant articles and documents

Multifactorial control of iteration events in a modular polyketide assembly line

Freedom and control: First insights into the rare programmed iteration of an individual polyketide synthase (PKS) module were obtained from the analysis and mutation of aureothin (1) synthase. The first ketosynthase (KS) domain primes the PKS, allowing intermediate retrotransfer. Addition of a designated loading module results in a complete loss of iteration. The downstream KS functions as a gatekeeper for correct chain length. Copyright

Biomimetic studies on polyenes.

The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions. The reaction pathways provide insight into the biosynthesis of these complex natural products.

Studies on the biomimetic synthesis of SNF4435 C and D

(equation Presented) The biomimetic synthesis of the bicyclic core of the novel immunosuppresants SNF4435C and SNF4435D is reported. The core framework was efficiently generated from the all-trans tetraene precursor in one step and in good yield.