144062-00-0

Usage

General Description

1,2-Azetidinedicarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (S)- is a chemical compound with potential pharmaceutical applications. It is an ester derivative of 1,2-azetidinedicarboxylic acid, which is a key intermediate in the synthesis of various pharmaceutical compounds. The (S)- enantiomer of 1,2-Azetidinedicarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (S)- has been studied for its potential use as a building block in the synthesis of chiral drugs and as a potential precursor for the synthesis of biologically active compounds. Its unique structure and properties make it an interesting candidate for further research and development in the pharmaceutical industry.

Upstream product

• 107020-12-2 methyl N-tert-butyloxycarbonyl-L-azetidine-2-carboxylate 
• 501-53-1 benzyl chloroformate 
• 53844-02-3 benzyl N-(2-bromoethyl)carbamate 
• 25711-25-5 benzyl aziridine-1-carboxylate 
• 6832-16-2 methyl diazoacetate 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 174740-81-9 N-benzyloxycarbonyl-(S)-(-)-2-azetidine-carboxylic acid 
• 67-56-1 methanol 
• 25654-52-8 (2S)-1-(benzyloxycarbonyl)azetidine-2-carboxylic acid 

Downstream Products

• 186593-56-6 (S)-1-benzyloxycarbonyl-2-azetidinemethanol 
• 195607-11-5 (S)-2-(Bis-ethylsulfanyl-methyl)-azetidine-1-carboxylic acid benzyl ester 
• 195607-10-4 (S)-2-Formyl-azetidine-1-carboxylic acid benzyl ester 
• 144062-03-3 (S)-4,4-Diphenyl-3-oxa-1-aza-bicyclo[3.2.0]heptan-2-one 
• 144062-05-5 (S)-2-(Hydroxy-diphenyl-methyl)-azetidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement

We report enantioselective one-carbon ring expansion of aziridines to make azetidines as a new-to-nature activity of engineered "carbene transferase" enzymes. A laboratory-evolved variant of cytochrome P450BM3, P411-AzetS, not only exerts unparalleled stereocontrol (99:1 er) over a [1,2]-Stevens rearrangement but also overrides the inherent reactivity of aziridinium ylides, cheletropic extrusion of olefins, to perform a [1,2]-Stevens rearrangement. By controlling the fate of the highly reactive aziridinium ylide intermediates, these evolvable biocatalysts promote a transformation which cannot currently be performed using other catalyst classes.

AZETIDOBENZODIAZEPINE DIMERS AND CONJUGATES COMPRISING THEM FOR USE IN THE TREATMENT OF CANCER

A compound of formula IV: as well as drug-linkers and conjugates comprising this compound, and the use of the conjugates in treating cancer.

Selective cleavage of carbamate protecting groups from aziridines with otera's catalyst

Otera's distannoxane catalyst was found to promote the cleavage of carbamate groups from N-protected aziridines. This method enables the chemoselective cleavage of an aziridinyl N-carbobenzyloxy (Cbz) group in the presence of other N-Cbz groups. The selec

Enantioselective catalytic reductions of ketones with new four membered oxazaborolidines: Application to (S)-tetramisole

Enantioselective catalytic reduction of ketones with both the enantiomers of new four membered oxazaborolidines is described.