1440958-47-3

Upstream product

• 25115-74-6 4-cyano-4-phenylcyclohexanone 
• 51509-98-9 8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonitril 
• 56327-24-3 8-phenyl-1,4-dioxaspiro[4,5]decane-8-carboxaldehyde 
• 51510-00-0 (8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)methanol 
• 1429045-55-5 C₂₂H₂₁F₆NO₂ 

Relevant academic research and scientific papers

Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression

This report describes the synthesis, structure-activity relationships and activity of piperidine, homopiperidine, and azocane derivatives combining NK1 receptor (NK1R) antagonism and serotonin reuptake transporter (SERT) inhibition. Our studies culminated in the discovery of piperidine 2 and homopiperidine 8 as potent dual NK1R antagonists-SERT inhibitors. Compound 2 demonstrated significant activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists-SERT inhibitors may be useful in treating depression disorders.