144164-55-6

Upstream product

• 98818-44-1 (2S,4S,5S)-2-Benzyl-5-tert-butoxycarbonylamino-4-hydroxy-6-phenyl-hexanoic acid 
• 98818-50-9 (2S,4S,5S)-5-{[(1,1-dimethylethoxy)carbonyl]amino}-4-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-6-phenyl-2-(phenylmethyl)hexanoic acid 
• 146500-09-6 (2S,4S,5S)-2-<<(phenylmethoxy)carbonyl>amino>-5-<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 146500-06-3 (2S,4S,5S)-2-<<(phenylmethoxy)carbonyl>amino>-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-5-<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenylhexane 
• 620-05-3 iodomethylbenzene 
• 98818-42-9 (3S,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 
• 133333-27-4 tert-butyl (1S)-1-[(2S)-5-oxotetrahydrofuran-2-yl]-2-phenylethylcarbamate 
• 98818-41-8 (3R,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 
• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 

Downstream Products

• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 

Relevant academic research and scientific papers

A short approach to the synthesis of the ritonavir and lopinavir core and its C-3 epimer via cross metathesis

A short synthesis of hydroxyethylene dipeptide isostere, a core unit of the HIV-protease inhibitors ritonavir and lopinavir, its C-3 epimer and C2 symmetric diamino diol is described. The crucial aspects of the synthesis are self-cross metathesis and exploitation of C2-symmetric of the metathesis product 8 to obtain the required skeleton.

Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic

The synthesis of a differentially protected dipeptide mimic 10 in enantiomerically pure form is described.The key step involves the epimerization of the C-2 center of the lactone 4, hydrolysis and protection of the resulting hydroxy acid, followed by Curt